ANOMALOUS DOSE-RESPONSE RELATIONSHIP DUE TO ASSOCIATION COLLOIDAL BEHAVIOUR OF SOLUBLE AMPHIPHILIC COMPOUNDS

B ISOMAA, Henry Hägerstrand, Diana Toivola

Tutkimustuotos: LehtiartikkeliArtikkeliTieteellinenvertaisarvioitu

Abstrakti

Water-soluble amphiphiles may, above a certain concentration, form colloidal aggregates (micelles or liquid crystals). If such aggregates are formed, there may be a competition between the micelles or the liquid crystals and the biological target for the monomeric form of the amphiphile. This may reduce the number of monomers available for the biological target, which in turn may be reflected in concentration-dependent processes. Therefore, caution should be taken when examining dose-response with soluble amphiphiles forming micelles at low concentrations.
AlkuperäiskieliEi tiedossa
Sivut194–198
Sivumäärä5
JulkaisuAlternatives to Laboratory Animals
Vuosikerta19
TilaJulkaistu - 1991
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

Keywords

  • AMPHIPHILE
  • DOSE-RESPONSE
  • CRITICAL MICELLE CONCENTRATION
  • hemolysis
  • erythrocyte membrane

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