Anionic cellulose beads for drug encapsulation and release

Jani Trygg, Emrah Yildir, Ruzica Kolakovic, Niklas Sandler, Pedro Fardim

Tutkimustuotos: LehtiartikkeliArtikkeliTieteellinenvertaisarvioitu

22 Sitaatiot (Scopus)

Abstrakti

Cellulose beads were prepared from water-based solvent and oxidised by modified Anelli's reaction at 20- for 2-48 h (Fig. 1). The maximum amount of anionic groups (AGs) was . The distribution of AGs was verified by absorption of cationic dyes and imaging with confocal fluorescent microscopy. Structural changes were studied spectroscopically and with electron microscopy. Oxidation of the beads drastically increased the swelling capacity of air-dried beads. Uptake of model drug was more than doubled in never-dried beads. This is due to the changes in pore size distribution, mainly opening and widening of the closed pores and narrow cavities. Release profiles of the drug were studied at physiological pH of 7.4 and showed a controlled release rate independently of the amount of the drug encapsulated and amount of AGs.
AlkuperäiskieliEi tiedossa
Sivut1945–1955
JulkaisuCellulose
Vuosikerta21
Numero3
DOI - pysyväislinkit
TilaJulkaistu - 2014
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

Keywords

  • TEMPO oxidation
  • Cellulose beads
  • Microspheres
  • drug delivery

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