Abstrakti
A label-free single-molecule detection platform based on biofunctionalized organic transistors has been recently proposed. In contrast to state-of-art approaches based on nano-transducers, the aforementioned single-molecule transistor (SiMoT) sensing technology is based on millimeter-sized transistors where the gate is bio-functionalized with about a trillion of antibodies. In this work we provide a detailed investigation of SiMoT biosensors by studying and quantifying the device parameters affected by the biorecognition event. The study combines both measurements and theoretical analyses, showing that a single protein detection taking place at nanometer scale affects a millimeter scale area of the biofunctionalized gate electrode. The dimension of the bioprobe domains affected by the binding is calculated as a function of the nominal protein concentration in the analyte solution. These results provide important insight into the SiMoT biosensor technology, which can guide the development of multi-modal SiMoT detection and integrated SiMoT biosensors arrays.
Alkuperäiskieli | Ei tiedossa |
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Otsikko | 2019 IEEE 8th International Workshop on Advances in Sensors and Interfaces (IWASI) |
Kustantaja | IEEE |
Sivut | 70–74 |
Sivumäärä | 5 |
ISBN (elektroninen) | 978-1-7281-0557-4 |
ISBN (painettu) | 978-1-7281-0558-1 |
DOI - pysyväislinkit | |
Tila | Julkaistu - 2019 |
OKM-julkaisutyyppi | A4 Artikkeli konferenssijulkaisuussa |
Tapahtuma | International Workshop on Advances in Sensors and Interfaces - 8th International Workshop on Advances in Sensors and Interfaces Kesto: 13 kesäk. 2019 → 14 kesäk. 2019 |
Konferenssi
Konferenssi | International Workshop on Advances in Sensors and Interfaces |
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Ajanjakso | 13/06/19 → 14/06/19 |
Keywords
- biofunctionalization
- biosensor
- organic transistor
- single molecule