TY - JOUR
T1 - An impedance QCM study on the partitioning of bioactive compounds in supported phospholipid bilayers
AU - Kannisto, Klaara
AU - Murtomäki, Lasse
AU - Viitala, Tapani
N1 - Funding Information:
Tapani Viitala acknowledges support from the Academy of Finland (grant nos. 137053 and 140980 ).
PY - 2011/9/1
Y1 - 2011/9/1
N2 - The interaction of two drugs of small molecular size, propranolol and tetracaine, and the membrane-perturbing peptide melittin with a phospholipid bilayer supported on a SiO2 surface was studied with the quartz crystal microbalance. All three bioactive compounds interacted with the lipid bilayer and changed its viscoelastic properties. Adsorbed mass of the compounds was analyzed with a viscoelastic model as a function of the concentration of the compounds in the aqueous phase, as well as the effect of the compounds on the bilayer viscoelasticity. The analysis was based on the interpretation of the impedance of the crystal, utilizing the 5th, 7th and 9th overtone of the fundamental 5MHz resonance frequency.
AB - The interaction of two drugs of small molecular size, propranolol and tetracaine, and the membrane-perturbing peptide melittin with a phospholipid bilayer supported on a SiO2 surface was studied with the quartz crystal microbalance. All three bioactive compounds interacted with the lipid bilayer and changed its viscoelastic properties. Adsorbed mass of the compounds was analyzed with a viscoelastic model as a function of the concentration of the compounds in the aqueous phase, as well as the effect of the compounds on the bilayer viscoelasticity. The analysis was based on the interpretation of the impedance of the crystal, utilizing the 5th, 7th and 9th overtone of the fundamental 5MHz resonance frequency.
KW - Adsorption
KW - Phospholipid bilayer
KW - Quartz crystal microbalance
KW - Viscoelasticity
UR - http://www.scopus.com/inward/record.url?scp=79957635899&partnerID=8YFLogxK
U2 - 10.1016/j.colsurfb.2011.04.012
DO - 10.1016/j.colsurfb.2011.04.012
M3 - Article
C2 - 21549577
AN - SCOPUS:79957635899
SN - 0927-7765
VL - 86
SP - 298
EP - 304
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
IS - 2
ER -