An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes – application to establishing CYP2C8 inhibitor selectivity

Helinä Kahma; Laura Aurinsalo; Mikko Neuvonen; Jani Katajamäki; Marie-Noëlle Paludetto; Jenni Viinamäki; Terhi Launiainen; Anne M. Filppula; Aleksi Tornio; Mikko Niemi; Janne T. Backman

doi:10.1016/j.ejps.2021.105810

An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes – application to establishing CYP2C8 inhibitor selectivity

Helinä Kahma
, Laura Aurinsalo
, Mikko Neuvonen
, Jani Katajamäki
, Marie-Noëlle Paludetto
, Jenni Viinamäki
, Terhi Launiainen
, Anne M. Filppula
, Aleksi Tornio
, Mikko Niemi
, Janne T. Backman

Tutkimustuotos: Lehtiartikkeli › Artikkeli › Tieteellinen › vertaisarvioitu

19 Sitaatiot (Scopus)

167 Lataukset (Pure)

Alkuperäiskieli	Englanti
Artikkeli	105810
Julkaisu	European Journal of Pharmaceutical Sciences
Vuosikerta	162
DOI - pysyväislinkit	https://doi.org/10.1016/j.ejps.2021.105810
Tila	Julkaistu - heinäk. 2021
Julkaistu ulkoisesti	Kyllä
OKM-julkaisutyyppi	A1 Julkaistu artikkeli, soviteltu

Pääsy asiakirjaan

10.1016/j.ejps.2021.105810

1-s2.0-S0928098721001123-mainLopullinen julkaistu versio, 2,86 MBLisenssi: CC BY-NC-ND

https://urn.fi/URN:NBN:fi-fe2022030421819

Muut tiedostot ja linkit

https://doi.org/10.1016/j.ejps.2021.105810

Viittausmuodot

Kahma, H., Aurinsalo, L., Neuvonen, M., Katajamäki, J., Paludetto, M.-N., Viinamäki, J., Launiainen, T., Filppula, A. M., Tornio, A., Niemi, M., & Backman, J. T. (2021). An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes – application to establishing CYP2C8 inhibitor selectivity. European Journal of Pharmaceutical Sciences, 162, Artikkeli 105810. https://doi.org/10.1016/j.ejps.2021.105810

@article{3408133ccacb44c0986298e77ca9d51c,

title = "An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes – application to establishing CYP2C8 inhibitor selectivity",

author = "Helin{\"a} Kahma and Laura Aurinsalo and Mikko Neuvonen and Jani Katajam{\"a}ki and Marie-No{\"e}lle Paludetto and Jenni Viinam{\"a}ki and Terhi Launiainen and Filppula, \{Anne M.\} and Aleksi Tornio and Mikko Niemi and Backman, \{Janne T.\}",

year = "2021",

month = jul,

doi = "10.1016/j.ejps.2021.105810",

language = "English",

volume = "162",

journal = "European Journal of Pharmaceutical Sciences",

issn = "0928-0987",

publisher = "Elsevier",

}

Kahma, H, Aurinsalo, L, Neuvonen, M, Katajamäki, J, Paludetto, M-N, Viinamäki, J, Launiainen, T, Filppula, AM, Tornio, A, Niemi, M & Backman, JT 2021, 'An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes – application to establishing CYP2C8 inhibitor selectivity', European Journal of Pharmaceutical Sciences, Vuosikerta 162, 105810. https://doi.org/10.1016/j.ejps.2021.105810

An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes – application to establishing CYP2C8 inhibitor selectivity. / Kahma, Helinä; Aurinsalo, Laura; Neuvonen, Mikko et al.
julkaisussa: European Journal of Pharmaceutical Sciences, Vuosikerta 162, 105810, 07.2021.

Tutkimustuotos: Lehtiartikkeli › Artikkeli › Tieteellinen › vertaisarvioitu

TY - JOUR

T1 - An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes – application to establishing CYP2C8 inhibitor selectivity

AU - Kahma, Helinä

AU - Aurinsalo, Laura

AU - Neuvonen, Mikko

AU - Katajamäki, Jani

AU - Paludetto, Marie-Noëlle

AU - Viinamäki, Jenni

AU - Launiainen, Terhi

AU - Filppula, Anne M.

AU - Tornio, Aleksi

AU - Niemi, Mikko

AU - Backman, Janne T.

PY - 2021/7

Y1 - 2021/7

UR - https://doi.org/10.1016/j.ejps.2021.105810

U2 - 10.1016/j.ejps.2021.105810

DO - 10.1016/j.ejps.2021.105810

M3 - Article

SN - 0928-0987

VL - 162

JO - European Journal of Pharmaceutical Sciences

JF - European Journal of Pharmaceutical Sciences

M1 - 105810

ER -

Kahma H, Aurinsalo L, Neuvonen M, Katajamäki J, Paludetto MN, Viinamäki J et al. An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes – application to establishing CYP2C8 inhibitor selectivity. European Journal of Pharmaceutical Sciences. 2021 heinäk.;162:105810. doi: 10.1016/j.ejps.2021.105810