Activation of the MKK4-JNK pathway during erythroid differentiation of K562 cells is inhibited by the heat shock factor 2-beta isoform

V Hietakangas, I Elo, H Rosenström, E T Coffey, J M Kyriakis, J E Eriksson, L Sistonen

Tutkimustuotos: LehtiartikkeliArtikkeliTieteellinenvertaisarvioitu

Abstrakti

In this study we report the activation of c-Jun N-terminal kinase (JNK) in human K562 erythroleukemia cells undergoing hemin-mediated erythroid differentiation, which occurs concomitantly with activation of heat shock factor 2 (HSF2) and leads to a simultaneous in vivo phosphorylation of c-Jun. The activation of JNK occurs through activation of mitogen-activated protein kinase kinase (MKK) 4 and not by activation of MKK7 or inhibition of JNK-directed phosphatases. We have previously shown that overexpression of the HSF2-beta isoform inhibits the activation of HSF2 upon hemin-induced erythroid differentiation. Here we demonstrate that HSF2-beta overexpression blocks the hemin-induced activation of the MKK4-JNK pathway, suggesting an erythroid lineage-specific JNK activation likely to be regulated by HSF2.

AlkuperäiskieliEnglanti
Sivut168-72
Sivumäärä5
JulkaisuFEBS Letters
Vuosikerta505
Numero1
DOI - pysyväislinkit
TilaJulkaistu - 7 syysk. 2001
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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