A New Mathematical Model for the Heat Shock Response

Ion Petre; A Mizera; Claire Hyder; A Mikhailov; John Eriksson; Lea Sistonen; Ralph-Johan Back

doi:10.1007/978-3-540-88869-7_21

A New Mathematical Model for the Heat Shock Response

Ion Petre, A Mizera, Claire Hyder, A Mikhailov, John Eriksson, Lea Sistonen, Ralph-Johan Back

Tutkimustuotos: Artikkeli kirjassa/raportissa/konferenssijulkaisussa › Luku › Tieteellinen › vertaisarvioitu

9 Sitaatiot (Scopus)

Abstrakti

We present in this paper a novel molecular model for the gene regulatory network responsible for the eukaryotic heat shock response. Our model includes the temperature-induced protein misfolding, the chaperone activity of the heat shock proteins, and the backregulation of their gene transcription. We then build a mathematical model for it, based on ordinary differential equations. Finally, we discuss the parameter fit and the implications of the sensitivity analysis for our model.

Alkuperäiskieli	Ei tiedossa
Otsikko	Algorithmic bioprocesses
Toimittajat	Anne Condon, David Harel, Joost N. Kok, Arto Salomaa, Erik Winfree
Kustantaja	Springer
Sivut	411–425
Sivumäärä	15
ISBN (painettu)	9783540888697
DOI - pysyväislinkit	https://doi.org/10.1007/978-3-540-88869-7_21
Tila	Julkaistu - 2009
OKM-julkaisutyyppi	A3 Kirjan osa tai toinen tutkimuskirja

Pääsy asiakirjaan

10.1007/978-3-540-88869-7_21

Viittausmuodot

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title = "A New Mathematical Model for the Heat Shock Response",

abstract = "We present in this paper a novel molecular model for the gene regulatory network responsible for the eukaryotic heat shock response. Our model includes the temperature-induced protein misfolding, the chaperone activity of the heat shock proteins, and the backregulation of their gene transcription. We then build a mathematical model for it, based on ordinary differential equations. Finally, we discuss the parameter fit and the implications of the sensitivity analysis for our model.",

author = "Ion Petre and A Mizera and Claire Hyder and A Mikhailov and John Eriksson and Lea Sistonen and Ralph-Johan Back",

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T1 - A New Mathematical Model for the Heat Shock Response

AU - Petre, Ion

AU - Mizera, A

AU - Hyder, Claire

AU - Mikhailov, A

AU - Eriksson, John

AU - Sistonen, Lea

AU - Back, Ralph-Johan

PY - 2009

Y1 - 2009

N2 - We present in this paper a novel molecular model for the gene regulatory network responsible for the eukaryotic heat shock response. Our model includes the temperature-induced protein misfolding, the chaperone activity of the heat shock proteins, and the backregulation of their gene transcription. We then build a mathematical model for it, based on ordinary differential equations. Finally, we discuss the parameter fit and the implications of the sensitivity analysis for our model.

AB - We present in this paper a novel molecular model for the gene regulatory network responsible for the eukaryotic heat shock response. Our model includes the temperature-induced protein misfolding, the chaperone activity of the heat shock proteins, and the backregulation of their gene transcription. We then build a mathematical model for it, based on ordinary differential equations. Finally, we discuss the parameter fit and the implications of the sensitivity analysis for our model.

U2 - 10.1007/978-3-540-88869-7_21

DO - 10.1007/978-3-540-88869-7_21

M3 - Kapitel

SN - 9783540888697

SP - 411

EP - 425

BT - Algorithmic bioprocesses

A2 - Condon, Anne

A2 - Harel, David

A2 - Kok, Joost N.

A2 - Salomaa, Arto

A2 - Winfree, Erik

PB - Springer

ER -