9-Norlignans: Occurrence, Properties and Their Semisynthetic Preparation from Hydroxymatairesinol

Patrik Christoffer Eklund, Jan-Erik Raitanen

Tutkimustuotos: LehtiartikkeliArtikkeliTieteellinenvertaisarvioitu

9 Sitaatiot (Scopus)

Abstrakti

Lignans, neolignans, norlignans and norneolignans constitute a large class of phenolic natural compounds. 9-Norlignans, here defined to contain a -' bond between the two phenylpropanoid units and to lack carbon number 9 from the parent lignan structure, are the most rarely occurring compounds within this class of natural compounds. We present here an overview of the structure, occurrence and biological activity of thirty-five 9-norlignans reported in the literature to date. In addition, we report the semisynthetic preparation of sixteen 9-norlignans using the natural lignan hydroxymatairesinol obtained from spruce knots, as starting material. 9-Norlignans are shown to exist in different species and to have various biological activities, and they may therefore serve as lead compounds for example for the development of anticancer agents. Hydroxymatairesinol is shown to be a readily available starting material for the preparation of norlignans of the imperanene, vitrofolal and noralashinol family.
AlkuperäiskieliEi tiedossa
Sivut
Sivumäärä12
JulkaisuMolecules
Vuosikerta24
Numero2
DOI - pysyväislinkit
TilaJulkaistu - 2019
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

Keywords

  • 9-norlignans
  • semisynthesis
  • bioactivity
  • norlignans

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