Whole-tissue biopsy phenotyping of three-dimensional tumours reveals patterns of cancer heterogeneity

Nobuyuki Tanaka; Shigeaki Kanatani; Raju Tomer; Cecilia Sahlgren; Pauliina Kronqvist; Dagmara Kaczynska; Lauri Louhivuori; Lorand Kis; Claes Lindh; Przemysław Mitura; Andrzej Stepulak; Sara Corvigno; Johan Hartman; Patrick Micke; Artur Mezheyeuski; Carina Strell; Joseph W. Carlson; Carlos Fernández Moro; Hanna Dahlstrand; Arne Östman; Kazuhiro Matsumoto; Peter Wiklund; Mototsugu Oya; Ayako Miyakawa; Karl Deisseroth; Per Uhlén

doi:10.1038/s41551-017-0139-0

Whole-tissue biopsy phenotyping of three-dimensional tumours reveals patterns of cancer heterogeneity

Nobuyuki Tanaka, Shigeaki Kanatani, Raju Tomer, Cecilia Sahlgren, Pauliina Kronqvist, Dagmara Kaczynska, Lauri Louhivuori, Lorand Kis, Claes Lindh, Przemysław Mitura, Andrzej Stepulak, Sara Corvigno, Johan Hartman, Patrick Micke, Artur Mezheyeuski, Carina Strell, Joseph W. Carlson, Carlos Fernández Moro, Hanna Dahlstrand, Arne ÖstmanKazuhiro Matsumoto, Peter Wiklund, Mototsugu Oya, Ayako Miyakawa, Karl Deisseroth, Per Uhlén

Research output: Contribution to journal › Article › Scientific › peer-review

144 Citations (Scopus)

Original language	Undefined/Unknown
Pages (from-to)	796–806
Journal	Nature Biomedical Engineering
Issue number	1
DOIs	https://doi.org/10.1038/s41551-017-0139-0
Publication status	Published - 2017
MoE publication type	A1 Journal article-refereed

Funding

This study was supported by the Swedish Research Council (grants 2009-3364, 2010-4392 and 2013-3189 to P.U.), the Swedish Cancer Society (grant CAN2013/802 and CAN2016/801 to P.U.), the Swedish Brain Foundation (grant FO2017/0107 to P.U.), the Linnaeus Center in Developmental Biology for Regenerative Medicine (DBRM) (P.U.), a Knut and Alice Wallenberg Foundation Grant to the Center for Live Imaging of Cells at the Karolinska (CLICK) Institutet (P.U.), the Royal Swedish Academy of Sciences (P.U.), the David and Astrid Hagelén Foundation (N.T.), the Takeda Science Foundation (N.T.), the Scandinavia-Japan Sasakawa Foundation (N.T. and S.K.), and the Wenner-Gren Foundation (S.K.). The light-sheet microscopy infrastructure used in this work received grants from the Strategic Research Area in Neuroscience – StratNeuro and the Strategic Research Area in Stem Cells and Regenerative Medicine – StratRegen supported by the Swedish government.

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10.1038/s41551-017-0139-0

Cite this

Tanaka, N., Kanatani, S., Tomer, R., Sahlgren, C., Kronqvist, P., Kaczynska, D., Louhivuori, L., Kis, L., Lindh, C., Mitura, P., Stepulak, A., Corvigno, S., Hartman, J., Micke, P., Mezheyeuski, A., Strell, C., Carlson, J. W., Fernández Moro, C., Dahlstrand, H., ... Uhlén, P. (2017). Whole-tissue biopsy phenotyping of three-dimensional tumours reveals patterns of cancer heterogeneity. Nature Biomedical Engineering, (1), 796–806. https://doi.org/10.1038/s41551-017-0139-0

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Tanaka, N, Kanatani, S, Tomer, R, Sahlgren, C, Kronqvist, P, Kaczynska, D, Louhivuori, L, Kis, L, Lindh, C, Mitura, P, Stepulak, A, Corvigno, S, Hartman, J, Micke, P, Mezheyeuski, A, Strell, C, Carlson, JW, Fernández Moro, C, Dahlstrand, H, Östman, A, Matsumoto, K, Wiklund, P, Oya, M, Miyakawa, A, Deisseroth, K & Uhlén, P 2017, 'Whole-tissue biopsy phenotyping of three-dimensional tumours reveals patterns of cancer heterogeneity', Nature Biomedical Engineering, no. 1, pp. 796–806. https://doi.org/10.1038/s41551-017-0139-0

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AU - Tanaka, Nobuyuki

AU - Kanatani, Shigeaki

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AU - Sahlgren, Cecilia

AU - Kronqvist, Pauliina

AU - Kaczynska, Dagmara

AU - Louhivuori, Lauri

AU - Kis, Lorand

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AU - Strell, Carina

AU - Carlson, Joseph W.

AU - Fernández Moro, Carlos

AU - Dahlstrand, Hanna

AU - Östman, Arne

AU - Matsumoto, Kazuhiro

AU - Wiklund, Peter

AU - Oya, Mototsugu

AU - Miyakawa, Ayako

AU - Deisseroth, Karl

AU - Uhlén, Per

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