Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress.

Nicole C. A. van Engeland; Freddy Suarez Rodriguez; Adolfo Rivero-Müller; Tommaso Ristori; Camille L. Duran; Oscar M. J. A. Stassen; Daniel Antfolk; Rob C. H. Driessen; Saku Ruohonen; Suvi T.  Ruohonen; Salla Nuutinen; Eriika Savontaus; Sandra Loerakker; Kayla J. Bayless; Marika Sjöqvist; Carlijn V. C. Bouten; John E. Eriksson; Cecilia M. Sahlgren

doi:10.1038/s41598-019-48218-w

Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress.

Nicole C. A. van Engeland
, Freddy Suarez Rodriguez
, Adolfo Rivero-Müller
, Tommaso Ristori
, Camille L. Duran
, Oscar M. J. A. Stassen
, Daniel Antfolk
, Rob C. H. Driessen
, Saku Ruohonen
, Suvi T. Ruohonen
, Salla Nuutinen
, Eriika Savontaus
, Sandra Loerakker
, Kayla J. Bayless
, Marika Sjöqvist
, Carlijn V. C. Bouten
, John E. Eriksson
, Cecilia M. Sahlgren

Research output: Contribution to journal › Article › Scientific › peer-review

78 Citations (Scopus)

85 Downloads (Pure)

Original language	English
Pages (from-to)	–
Journal	Scientific Reports
Volume	9
DOIs	https://doi.org/10.1038/s41598-019-48218-w
Publication status	Published - 2019
MoE publication type	A1 Journal article-refereed

Funding

This work has been supported by the Academy of Finland project number 218062, the ERC-CoG 771168-ForceMorph. Nicole van Engeland and Daniel Antfolk were supported by Åbo Akademi (MolBio). This project was also supported by The Finnish Foundation for Cardiovascular Research (Daniel Antfolk), Maud Kuistila Memorial Foundation, The Swedish Cultural Foundation in Finland (Daniel Antfolk and Marika Sjöqvist) and Einar & Karin Stroems foundation (Marika Sjöqvist). Oscar Stassen received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 60451, project Imavalve. The authors declare no competing financial interests.

Keywords

Vimentin
Notch signaling
intermediate filament
arterial remodeling
hemodynamic stress

Access to Document

10.1038/s41598-019-48218-w

2019 Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress (van Engeland and Suarez Rodriguez et al.) Sci RepFinal published version, 2.24 MBLicence: CC BY

https://urn.fi/URN:NBN:fi-fe202201147296

CellMech: Center of Excellence in Cellular Mechanostasis
Sahlgren, C. (Principal Investigator), Sistonen, L. (Principal Investigator), Eriksson, J. (Principal Investigator), Toivola, D. (Principal Investigator), Meinander, A. (Principal Investigator), Cheng, F. (Principal Investigator) & Jacquemet, G. (Principal Investigator)
01/03/19 → 29/02/24
Project: Foundation
ForceMorph: The integration of cell signalling and mechanical forces in vascular morphology
Sahlgren, C. (Principal Investigator)
European Research Council
01/03/18 → 31/08/23
Project: EU

Cite this

van Engeland, N. C. A., Suarez Rodriguez, F., Rivero-Müller, A., Ristori, T., Duran, C. L., Stassen, O. M. J. A., Antfolk, D., Driessen, R. C. H., Ruohonen, S., Ruohonen, S. T., Nuutinen, S., Savontaus, E., Loerakker, S., Bayless, K. J., Sjöqvist, M., Bouten, C. V. C., Eriksson, J. E., & Sahlgren, C. M. (2019). Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress. Scientific Reports, 9, –. https://doi.org/10.1038/s41598-019-48218-w

@article{65f43d3752604ed792077868ede7ac7b,

title = "Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress.",

keywords = "Vimentin, Notch signaling, intermediate filament, arterial remodeling, hemodynamic stress",

author = "\{van Engeland\}, \{Nicole C. A.\} and \{Suarez Rodriguez\}, Freddy and Adolfo Rivero-M{\"u}ller and Tommaso Ristori and Duran, \{Camille L.\} and Stassen, \{Oscar M. J. A.\} and Daniel Antfolk and Driessen, \{Rob C. H.\} and Saku Ruohonen and Ruohonen, \{Suvi T.\} and Salla Nuutinen and Eriika Savontaus and Sandra Loerakker and Bayless, \{Kayla J.\} and Marika Sj{\"o}qvist and Bouten, \{Carlijn V. C.\} and Eriksson, \{John E.\} and Sahlgren, \{Cecilia M.\}",

year = "2019",

doi = "10.1038/s41598-019-48218-w",

language = "English",

volume = "9",

pages = "–",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Research",

}

van Engeland, NCA, Suarez Rodriguez, F, Rivero-Müller, A, Ristori, T, Duran, CL, Stassen, OMJA, Antfolk, D, Driessen, RCH, Ruohonen, S, Ruohonen, ST, Nuutinen, S, Savontaus, E, Loerakker, S, Bayless, KJ, Sjöqvist, M, Bouten, CVC, Eriksson, JE & Sahlgren, CM 2019, 'Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress.', Scientific Reports, vol. 9, pp. –. https://doi.org/10.1038/s41598-019-48218-w

TY - JOUR

T1 - Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress.

AU - van Engeland, Nicole C. A.

AU - Suarez Rodriguez, Freddy

AU - Rivero-Müller, Adolfo

AU - Ristori, Tommaso

AU - Duran, Camille L.

AU - Stassen, Oscar M. J. A.

AU - Antfolk, Daniel

AU - Driessen, Rob C. H.

AU - Ruohonen, Saku

AU - Ruohonen, Suvi T.

AU - Nuutinen, Salla

AU - Savontaus, Eriika

AU - Loerakker, Sandra

AU - Bayless, Kayla J.

AU - Sjöqvist, Marika

AU - Bouten, Carlijn V. C.

AU - Eriksson, John E.

AU - Sahlgren, Cecilia M.

PY - 2019

Y1 - 2019

KW - Vimentin

KW - Notch signaling

KW - intermediate filament

KW - arterial remodeling

KW - hemodynamic stress

U2 - 10.1038/s41598-019-48218-w

DO - 10.1038/s41598-019-48218-w

M3 - Article

SN - 2045-2322

VL - 9

SP - –

JO - Scientific Reports

JF - Scientific Reports

ER -

Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress.

Funding

Keywords

Access to Document

Projects

CellMech: Center of Excellence in Cellular Mechanostasis

ForceMorph: The integration of cell signalling and mechanical forces in vascular morphology

Cite this