Abstract
As a member of the large family of intermediate filaments (IFs), vimentin has emerged as a highly dynamic and versatile cytoskeletal protein involved in many key processes of wound healing. It is well established that vimentin is involved in epithelial–mesenchymal transition (EMT) during wound healing and metastasis, during which epithelial cells acquire more dynamic and motile characteristics. Moreover, vimentin participates in multiple cellular activities supporting growth, proliferation, migration, cell survival, and stress resilience. Here, we explore the role of vimentin at each phase of wound healing, with focus on how it integrates different signaling pathways and protects cells in the fluctuating and challenging environments that characterize a healing tissue.
| Original language | English |
|---|---|
| Pages (from-to) | 239-254 |
| Number of pages | 16 |
| Journal | Trends in Cell Biology |
| Volume | 34 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2024 |
| MoE publication type | A2 Review article in a scientific journal |
Funding
This work was supported by Academy of Finland , Sigrid Jusélius Foundation , Magnus Ehrnrooth Foundation , K. Albin Johanssons Stiftelse , Otto A. Malm Foundation, Finnish Cultural Foundation, Swedish Cultural Foundation, Ella and Georg Ehrnrooth Foundation, and Instrumentarium Science Foundation. We thank Solveig Eriksson for excellent help with the graphical design of the figures.
Keywords
- EMT
- intermediate filaments
- tissue repair
- vimentin
- wound healing