Abstract
RNA forms of CRISPR-Cas9-based gene therapies provide more safer and effective therapeutic outcomes. This paper offers a reference for improving the effects of RNA forms of CRISPR-Cas9-based therapies, through the rational engineering design of mRNA components, combined with novel structural RNAs and novel delivery vehicles.
| Original language | English |
|---|---|
| Article number | 102737 |
| Journal | Molecular Therapy Nucleic Acids |
| Volume | 36 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Dec 2025 |
| MoE publication type | A2 Review article in a scientific journal |
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Åbo Akademi Functional Printing Center
Toivakka, M. (PI), Rosenholm, J. (PI), Anttu, N. (PI), Bobacka, J. (PI), Huynh, T. P. (PI), Peltonen, J. (PI), Wang, X. (PI), Wilen, C.-E. (PI), Xu, C. (PI), Zhang, H. (PI) & Österbacka, R. (PI)
Faculty of Science and EngineeringFacility/equipment: Facility
Projects
- 2 Active
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PII: Printed Intelligence Infrastructure
Toivakka, M. (Principal Investigator), Xu, C. (Co-Principal Investigator), Bobacka, J. (Co-Principal Investigator), Viitala, T. (Co-Principal Investigator), Rosenholm, J. (Co-Principal Investigator), Österbacka, R. (Co-Principal Investigator), Anttu, N. (Co-Principal Investigator), Huynh, T. P. (Co-Principal Investigator), Peltonen, J. (Co-Principal Investigator), Wang, X. (Co-Principal Investigator), Zhang, H. (Co-Principal Investigator) & Wilen, C.-E. (Co-Principal Investigator)
01/01/24 → 31/12/28
Project: Research Council of Finland/Other Research Councils
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MADNESS: Centre of Excellence in Materials-driven solutions for combatting antimicrobial resistance
Rosenholm, J. (Principal Investigator), Porres Paltor, I. (Co-Principal Investigator), Bansal, K. (Coordinator), Lafond, S. (Co-Principal Investigator), Uppstu, P. (Co-Principal Investigator), Viitala, T. (Co-Principal Investigator), Wang, X. (Co-Principal Investigator), Wilen, C.-E. (Co-Principal Investigator), Xu, C. (Co-Principal Investigator), Zhang, H. (Co-Principal Investigator), Lu, Z. (Co-Investigator), Verma, J. (Co-Investigator), Kumar, V. (Co-Investigator), Frejborg, F. (Co-Investigator), Wang, S. (Co-Investigator), Ran, M. (Co-Investigator), Ma, X. (Co-Investigator), Yang, W. (Co-Investigator), Liang, S. (Co-Investigator), Zhang, Y. (Co-Investigator), Fan, L. (Co-Investigator), Chen, Y. (Co-Investigator), Wang, L. (Co-Investigator), Zhuang, P. (Co-Investigator), Rajan Prakash, D. (Co-Investigator), Howaili, F. (Co-Investigator), Gulshan, R. (Co-Investigator), Yadav, D. (Co-Investigator), Pathak, C. (Co-Investigator), Mustafa, R. (Co-Investigator), Rostami, L. (Co-Investigator), Jafari Dargahlou, M. (Co-Investigator), Nygård, A. (Co-Investigator) & Manasut, P. (Co-Investigator)
01/01/24 → 31/12/28
Project: Foundation
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