Umbilical cord blood DNA methylation in children who later develop type 1 diabetes

Essi Laajala, Ubaid Ullah Kalim, Toni Grönroos, Omid Rasool, Viivi Halla-aho, Mikko Konki, Roosa Kattelus, Juha Mykkänen, Mirja Nurmio, Mari Vähä-Mäkilä, Henna Kallionpää, Niina Lietzén, Bishwa R. Ghimire, Asta Laiho, Heikki Hyöty, Laura L. Elo, Jorma Ilonen, Mikael Knip, Riikka J. Lund, Matej OrešičRiitta Veijola, Harri Lähdesmäki, Jorma Toppari, Riitta Lahesmaa*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

3 Citations (Scopus)
21 Downloads (Pure)

Abstract

Aims/hypothesis: Distinct DNA methylation patterns have recently been observed to precede type 1 diabetes in whole blood collected from young children. Our aim was to determine whether perinatal DNA methylation is associated with later progression to type 1 diabetes. Methods: Reduced representation bisulphite sequencing (RRBS) analysis was performed on umbilical cord blood samples collected within the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) Study. Children later diagnosed with type 1 diabetes and/or who tested positive for multiple islet autoantibodies (n = 43) were compared with control individuals (n = 79) who remained autoantibody-negative throughout the DIPP follow-up until 15 years of age. Potential confounding factors related to the pregnancy and the mother were included in the analysis. Results: No differences in the umbilical cord blood methylation patterns were observed between the cases and controls at a false discovery rate <0.05. Conclusions/interpretation: Based on our results, differences between children who progress to type 1 diabetes and those who remain healthy throughout childhood are not yet present in the perinatal DNA methylome. However, we cannot exclude the possibility that such differences would be found in a larger dataset. Graphical abstract: [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)1534-1540
Number of pages7
JournalDiabetologia
Volume65
Issue number9
DOIs
Publication statusPublished - Sept 2022
MoE publication typeA1 Journal article-refereed

Keywords

  • Bisulphite sequencing
  • DNA methylation
  • Epigenomics
  • Follow-up study
  • Type 1 diabetes
  • Umbilical cord blood

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