UiO-66-NH2 as a novel ultrahigh-selective adsorbent superior to molecularly imprinted polymers for the adsorption of artesunate

Minjia Meng*, Suao Wang, Jingyi Dai, Yi Li, Yonghai Feng, Yu Zhu, Hongbo Zhang, Yan Li

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

5 Citations (Scopus)

Abstract

In this work, a simple metal-organic framework (MOF) material, UiO-66-NH 2, was prepared for the highly efficient separation of artemisinin (Art) and artesunate (Aru). Selective adsorption tests showed that UiO-66-NH 2 presented a much higher selectivity toward Aru than Art (α Aru/Art = 40.74). The N 2 adsorption-desorption isotherm results of UiO-66-NH 2 indicated a suitable pore size to enable the free entry of Art and Aru. Contact angle analysis indicated that UiO-66-NH 2 is hydrophilic with the -NH 2 group, and can interact with the hydrophobic Aru through hydrogen bonding between the -NH 2 and -COOH groups, which is not possible with the hydrophobic Art. The selective adsorption of Aru onto UiO-66-NH 2 may be attributed to three factors: pore size, functional groups, and difference in hydrophobic/hydrophilic characteristics between the adsorbent and adsorbate. Molecularly imprinted polymers (MIPs) were prepared using Aru as a template for selective adsorption experiments to verify the excellent selectivity of UiO-66-NH 2. The adsorption amount (65.24 mg g −1) and selectivity factor (α Aru/Art = 40.74) of UiO-66-NH 2 toward Aru were significantly better than those of the MIPs (2.039 mg g −1 and 3.072, respectively). The binding capacity and better selectivity of UiO-66-NH 2 provide evidence supporting the potential of MOF adsorbents for the separation of various analogous molecules.

Original languageEnglish
Article number128830
JournalColloids and Surfaces A: Physicochemical and Engineering Aspects
Volume644
DOIs
Publication statusPublished - 5 Jul 2022
MoE publication typeA1 Journal article-refereed

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