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Abstract
In this work, a simple metal-organic framework (MOF) material, UiO-66-NH 2, was prepared for the highly efficient separation of artemisinin (Art) and artesunate (Aru). Selective adsorption tests showed that UiO-66-NH 2 presented a much higher selectivity toward Aru than Art (α Aru/Art = 40.74). The N 2 adsorption-desorption isotherm results of UiO-66-NH 2 indicated a suitable pore size to enable the free entry of Art and Aru. Contact angle analysis indicated that UiO-66-NH 2 is hydrophilic with the -NH 2 group, and can interact with the hydrophobic Aru through hydrogen bonding between the -NH 2 and -COOH groups, which is not possible with the hydrophobic Art. The selective adsorption of Aru onto UiO-66-NH 2 may be attributed to three factors: pore size, functional groups, and difference in hydrophobic/hydrophilic characteristics between the adsorbent and adsorbate. Molecularly imprinted polymers (MIPs) were prepared using Aru as a template for selective adsorption experiments to verify the excellent selectivity of UiO-66-NH 2. The adsorption amount (65.24 mg g −1) and selectivity factor (α Aru/Art = 40.74) of UiO-66-NH 2 toward Aru were significantly better than those of the MIPs (2.039 mg g −1 and 3.072, respectively). The binding capacity and better selectivity of UiO-66-NH 2 provide evidence supporting the potential of MOF adsorbents for the separation of various analogous molecules.
Original language | English |
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Article number | 128830 |
Journal | Colloids and Surfaces A: Physicochemical and Engineering Aspects |
Volume | 644 |
DOIs | |
Publication status | Published - 5 Jul 2022 |
MoE publication type | A1 Journal article-refereed |
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Åbo Akademi Functional Printing Center
Toivakka, M. (PI), Rosenholm, J. (PI), Anttu, N. (PI), Bobacka, J. (PI), Huynh, T. P. (PI), Peltonen, J. (PI), Wang, X. (PI), Wilen, C.-E. (PI), Xu, C. (PI), Zhang, H. (PI) & Österbacka, R. (PI)
Faculty of Science and EngineeringFacility/equipment: Facility
Projects
- 2 Finished
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FCFH: Finland-China Network in Food and Health Sciences
Rosenholm, J. (Principal Investigator), Xu, C. (Principal Investigator) & Zhang, H. (Principal Investigator)
Ministry of Education and Culture
01/01/21 → 31/12/24
Project: Ministry / Government Agency
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Targeted delivery of CRISPR/Cas9 for advanced liver cancer therapy through c-Myc knockout
Zhang, H. (Principal Investigator)
01/09/19 → 31/08/24
Project: Research Council of Finland/Other Research Councils