UBR5 Is Coamplified with MYC in Breast Tumors and Encodes an Ubiquitin Ligase That Limits MYC-Dependent Apoptosis

Xi Qiao, Ying Liu, Maria Llamazares Prada, Aravind K Mohan, Abhishekh Gupta, Alok Jaiswal, Mukund Sharma, Joni Merisaari, Heidi M Haikala, Kati Talvinen, Laxman Yetukuri, Joanna W Pylvänäinen, Juha Klefström, Pauliina Kronqvist, Annika Meinander, Tero Aittokallio, Ville Hietakangas, Martin Eilers, Jukka Westermarck

Research output: Contribution to journalArticleScientificpeer-review

2 Citations (Scopus)
Original languageEnglish
Pages (from-to)1414-1427
Number of pages14
JournalCancer Research
Volume80
Issue number7
DOIs
Publication statusPublished - 1 Apr 2020
MoE publication typeA1 Journal article-refereed

Keywords

  • Animals
  • Animals, Genetically Modified
  • Apoptosis/genetics
  • Breast/pathology
  • Breast Neoplasms/genetics
  • Cell Line, Tumor
  • DNA-Binding Proteins/genetics
  • Drosophila Proteins/genetics
  • Female
  • Gene Amplification
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Kaplan-Meier Estimate
  • Models, Animal
  • Protein Stability
  • Proto-Oncogene Proteins c-myc/genetics
  • RNA-Seq
  • Tissue Array Analysis
  • Transcription Factors/genetics
  • Ubiquitin-Protein Ligases/genetics
  • Ubiquitination/genetics

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