Tubulin polymerization inhibitors

Sanjeev Kumar Sahu; Manish Chaudhary; Shweta Jain; Kuldeep Kumar Bansal

doi:10.1016/B978-0-323-96121-9.00015-2

Tubulin polymerization inhibitors

Sanjeev Kumar Sahu, Manish Chaudhary, Shweta Jain, Kuldeep Kumar Bansal

Pharmacy

Research output: Chapter in Book/Conference proceeding › Chapter › Scientific › peer-review

Abstract

Tubulin polymerization is an essential phenomenon for the cell division process (mitosis). In cancer disease, there is a rapid or uncontrolled multiplication of cells, and this can be prevented by inhibition of microtubule formation that is inhibition of tubulin polymerization. In this chapter, microtubules, structure, and function along with the mechanism and domains of microtubules are discussed. In addition, based on domains or sites, various inhibitors of polymerization are also being discussed.

Original language	English
Title of host publication	Current Molecular Targets of Heterocyclic Compounds for Cancer Therapy
Publisher	Elsevier
Pages	395-417
Number of pages	23
ISBN (Electronic)	9780323961219
ISBN (Print)	9780323996327
DOIs	https://doi.org/10.1016/B978-0-323-96121-9.00015-2
Publication status	Published - 1 Jan 2024
MoE publication type	A3 Part of a book or another research book

Keywords

Colchicine
Hydrolysis
Microtubules
Mitosis
Tubulin
Vinblastine

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10.1016/B978-0-323-96121-9.00015-2

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AU - Jain, Shweta

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KW - Colchicine

KW - Hydrolysis

KW - Microtubules

KW - Mitosis

KW - Tubulin

KW - Vinblastine

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SN - 9780323996327

SP - 395

EP - 417

BT - Current Molecular Targets of Heterocyclic Compounds for Cancer Therapy

PB - Elsevier

ER -

Tubulin polymerization inhibitors

Abstract

Keywords

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