Traumatic injury to CNS fiber tracts - What are the genes telling us?

Daniel Abankwa, P Kury

Research output: Contribution to journalArticleScientificpeer-review

3 Citations (Scopus)


In contrast to the peripheral nervous system (PNS) nerve fiber tracts of the adult central nervous system (CNS) cannot spontaneously regenerate in response to lesions. As a result injured individuals suffer from chronically impaired neuronal connections leading to major motor-, sensory- and cognitive deficits. It is generally assumed that combinatorial effects account for this regeneration failure including a growth non-permissive environment within CNS lesion zones as well as incomplete activation of axonal growth programmes. In order to design CNS repair strategies it is, therefore, imperative to address the molecular mechanisms responsible for this abortive growth behaviour by means of large scale screening techniques. This review summarizes the outcome of recent gene expression profiling studies investigating local and remote molecular reactions following CNS axotomy.
Original languageUndefined/Unknown
Pages (from-to)647–654
Number of pages8
JournalCurrent Drug Targets
Issue number7
Publication statusPublished - 2004
MoE publication typeA1 Journal article-refereed


  • axotomy
  • CNS
  • DNA array technology
  • gene expression patterns
  • lesion site
  • nerve regeneration
  • PNS
  • spinal cord injury

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