Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion

Muhammad Yasir Asghar, Kid Törnquist

Research output: Contribution to journalReview Article or Literature Reviewpeer-review

1 Citation (Scopus)

Abstract

Calcium (Ca2+) is perhaps the most versatile signaling molecule in cells. Ca2+ regulates a large number of key events in cells, ranging from gene transcription, motility, and contraction, to energy production and channel gating. To accomplish all these different functions, a multitude of channels, pumps, and transporters are necessary. A group of channels participating in these processes is the transient receptor potential (TRP) family of cation channels. These channels are divided into 29 subfamilies, and are differentially expressed in man, rodents, worms, and flies. One of these subfamilies is the transient receptor potential canonical (TRPC) family of channels. This ion channel family comprises of seven isoforms, labeled TRPC1–7. In man, six functional forms are expressed (TRPC1, TRPC3–7), whereas TRPC2 is a pseudogene; thus, not functionally expressed. In this review, we will describe the importance of the TRPC channels and their interacting molecular partners in the etiology of cancer, particularly in regard to regulating migration and invasion.
Original languageEnglish
Article number1739
JournalInternational Journal of Molecular Sciences
Volume21
Issue number5
DOIs
Publication statusPublished - 2020
MoE publication typeA2 Review article in a scientific journal

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