Towards clinical PET imaging of pancreatic beta cells with [F-18]exendin-4

K Mikkola; CB Yim; P Lehtiniemi; VV Elomaa; T Ishizu; Johan Rajander; O Solin; P Nuutila

doi:10.1007/s00125-014-3355-0

Towards clinical PET imaging of pancreatic beta cells with [F-18]exendin-4

K Mikkola, CB Yim, P Lehtiniemi, VV Elomaa, T Ishizu, Johan Rajander, O Solin, P Nuutila

Research output: Contribution to journal › Article › Scientific › peer-review

2 Citations (Scopus)

Abstract

[18F]exendin-4 is a radioligand specific for the gluca- gon like peptide-1 receptor (GLP-1R) abundantly expressed in beta cells. Quantitative non-invasive PET (positron emission tomography) imaging of pancreatic beta cells would serve as a valuable diagnostic tool and provide means to monitor therapeutic interventions. Several exendin based tracers have been intensively explored for beta cell imaging. The obstacle with these has been high uptake in the kidneys. The aim of this study is to develop a novel [18F]exendin-4 tracer for clinical imaging of beta cells with PET.

Original language	Undefined/Unknown
Pages (from-to)	S188–S188
Number of pages	1
Journal	Diabetologia
Volume	57
DOIs	https://doi.org/10.1007/s00125-014-3355-0
Publication status	Published - 2014
MoE publication type	A1 Journal article-refereed

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10.1007/s00125-014-3355-0

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Cite this

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title = "Towards clinical PET imaging of pancreatic beta cells with [F-18]exendin-4",

abstract = "[18F]exendin-4 is a radioligand specific for the gluca- gon like peptide-1 receptor (GLP-1R) abundantly expressed in beta cells. Quantitative non-invasive PET (positron emission tomography) imaging of pancreatic beta cells would serve as a valuable diagnostic tool and provide means to monitor therapeutic interventions. Several exendin based tracers have been intensively explored for beta cell imaging. The obstacle with these has been high uptake in the kidneys. The aim of this study is to develop a novel [18F]exendin-4 tracer for clinical imaging of beta cells with PET. ",

author = "K Mikkola and CB Yim and P Lehtiniemi and VV Elomaa and T Ishizu and Johan Rajander and O Solin and P Nuutila",

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TY - JOUR

T1 - Towards clinical PET imaging of pancreatic beta cells with [F-18]exendin-4

AU - Mikkola, K

AU - Yim, CB

AU - Lehtiniemi, P

AU - Elomaa, VV

AU - Ishizu, T

AU - Rajander, Johan

AU - Solin, O

AU - Nuutila, P

PY - 2014

Y1 - 2014

N2 - [18F]exendin-4 is a radioligand specific for the gluca- gon like peptide-1 receptor (GLP-1R) abundantly expressed in beta cells. Quantitative non-invasive PET (positron emission tomography) imaging of pancreatic beta cells would serve as a valuable diagnostic tool and provide means to monitor therapeutic interventions. Several exendin based tracers have been intensively explored for beta cell imaging. The obstacle with these has been high uptake in the kidneys. The aim of this study is to develop a novel [18F]exendin-4 tracer for clinical imaging of beta cells with PET.

AB - [18F]exendin-4 is a radioligand specific for the gluca- gon like peptide-1 receptor (GLP-1R) abundantly expressed in beta cells. Quantitative non-invasive PET (positron emission tomography) imaging of pancreatic beta cells would serve as a valuable diagnostic tool and provide means to monitor therapeutic interventions. Several exendin based tracers have been intensively explored for beta cell imaging. The obstacle with these has been high uptake in the kidneys. The aim of this study is to develop a novel [18F]exendin-4 tracer for clinical imaging of beta cells with PET.

U2 - 10.1007/s00125-014-3355-0

DO - 10.1007/s00125-014-3355-0

M3 - Artikel

SN - 0012-186X

VL - 57

SP - S188–S188

JO - Diabetologia

JF - Diabetologia

ER -