Time-resolved SERS for characterizing extracellular vesicles

Tatu Rojalin*, Heikki Saari, Petter Somersalo, Saara Laitinen, Mikko Turunen, Tapani Viitala, Sebastian Wachsmann-Hogiu, Zachary J. Smith, Marjo Yliperttula

*Corresponding author for this work

Research output: Chapter in Book/Conference proceedingConference contributionScientificpeer-review


The aim of this work is to develop a platform for characterizing extracellular vesicles (EV) by using gold-polymer nanopillar SERS arrays simultaneously circumventing the photoluminescence-related disadvantages of Raman with a time-resolved approach. EVs are rich of biochemical information reporting of, for example, diseased state of the biological system. Currently, straightforward, label-free and fast EV characterization methods with low sample consumption are warranted. In this study, SERS spectra of red blood cell and platelet derived EVs were successfully measured and their biochemical contents analyzed using multivariate data analysis techniques. The developed platform could be conveniently used for EV analytics in general.

Original languageEnglish
Title of host publicationPlasmonics in Biology and Medicine XIV
EditorsTuan Vo-Dinh, Joseph R. Lakowicz
PublisherSPIE, The International Society for Optical Engineering
ISBN (Electronic)9781510606012
Publication statusPublished - 2017
Externally publishedYes
MoE publication typeA4 Article in a conference publication
EventPlasmonics in Biology and Medicine XIV - San Francisco, United States
Duration: 30 Jan 2017 → …

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferencePlasmonics in Biology and Medicine XIV
Country/TerritoryUnited States
CitySan Francisco
Period30/01/17 → …


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