Therapeutic Potential of Polymer-Coated Mesoporous Silica Nanoparticles

Kuldeep Bansal, Deepak K. Mishra, Ari Rosling, Jessica Rosenholm

Research output: Contribution to journalArticleScientificpeer-review

3 Citations (Scopus)
3 Downloads (Pure)

Abstract

Mesoporous silica nanoparticles (MSNs) find tremendous applications in drug delivery due to several advantages such as their easy fabrication process, high drug loading, biodegradability, biocompatibility, and so forth. Nevertheless, despite several advantages, the use of this striking drug delivery carrier is restricted due to premature drug release owing to the porous structure. Coating of the pores using polymers has emerged as a great solution to this problem. Polymer coatings, which act as gatekeepers, avoid the premature release of loaded content from MSNs and offers the opportunity for controlled and targeted drug delivery. Therefore, in this review, we have compiled the polymer-based coating approaches used in recent years for improving the drug delivery capability of MSNs. This manuscript provides an insight into the research about the potential of polymer-coated MSNs, allowing the selection of right polymer for coating purposes according to the desired application.

Original languageEnglish
Pages (from-to)
JournalApplied Sciences
Volume10
Issue number1
DOIs
Publication statusPublished - 2020
MoE publication typeA1 Journal article-refereed

Keywords

  • Drug delivery systems
  • drug delivery
  • Customized drug delivery device
  • Micro-Mesoporous material
  • mesoporous materials
  • drug-delivery systems
  • controlled drug delivery
  • polymer
  • Mesoporous silica

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