The role of Interleukin-32 in autoimmunity

Rafael de Albuquerque, Elina Komsi, Inna Starskaia, Ubaid Ullah, Riitta Lahesmaa

Research output: Contribution to journalReview Article or Literature Reviewpeer-review

Abstract

Abstract Interleukin-32 (IL-32) is a pro-inflammatory cytokine that induces other cytokines involved in inflammation, including tumour necrosis factor (TNF)-α, IL-6 and IL-1?. Recent evidence suggests that IL-32 has a crucial role in host defence against pathogens, as well as in the pathogenesis of chronic inflammation. Abnormal IL-32 expression has been linked to several autoimmune diseases, such as rheumatoid arthritis and inflammatory bowel diseases, and a recent study suggested the importance of IL-32 in the pathogenesis of type 1 diabetes. However, despite accumulating evidence, many molecular characteristics of this cytokine, including the secretory route and the receptor for IL-32, remain largely unknown. In addition, the IL-32 gene is found in higher mammals but not in rodents. In this review, we outline the current knowledge of IL-32 biological functions, properties, and its role in autoimmune diseases. We particularly highlight the role of IL-32 in rheumatoid arthritis and type 1 diabetes.
Original languageEnglish
JournalScandinavian Journal of Immunology
DOIs
Publication statusPublished - 2020
MoE publication typeA2 Review article in a scientific journal

Keywords

  • Interleukin-32
  • rheumatoid arthritis
  • type 1 diabetes

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