The plant lignans matairesinol and secoisolariciresinol administered to Min mice do not protect against intestinal tumor formation

Anne-Maria Pajari, Annika Smeds, Seija I. Oikarinen, Patrik Christoffer Eklund, Rainer Sjöholm, Marja Mutanen

    Research output: Contribution to journalArticleScientificpeer-review

    15 Citations (Scopus)

    Abstract

    The lignans matairesinol (MAT) and secoisolariciresinol (SECO) were fed to Min mice at 0.02% (w/w) in diet to study their effects on intestinal tumor development. The mean number (67 vs. 5 1, P = 0.052) and size (1.4 vs. 1.2 mm, P=0.011) of tumors in the MAT group was elevated when compared with the control group. Tumor formation of the SECO group did not differ from the control group. Intake of MAT increased the level of both MAT and enterolactone in the plasma while SECO feeding increased SECO, enterodiol, and enterolactone (P=0.001). These results showed that MAT or SECO do not prevent intestinal carcinogenesis in Min mice and that MAT may have adverse effects. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
    Original languageUndefined/Unknown
    Pages (from-to)309–314
    Number of pages6
    JournalCancer Letters
    Volume233
    Issue number2
    DOIs
    Publication statusPublished - 2006
    MoE publication typeA1 Journal article-refereed

    Keywords

    • colon cancer
    • matairesinol
    • Min mice
    • secoisolariciresinol

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