Abstract
Background: The rapid occurrence of bacterial antibiotic resistance poses a significant threat to public health worldwide. Since particularly multidrug-resistant (MDR) pathogens are becoming untreatable with currently available antibiotics, new treatment modalities must be deployed. Objectives: This review explores the recent advancements and the enduring challenges in new antibacterial development for drug-resistant organisms. Results: We describe how bacterial resistance to antibiotics arises and discuss why the traditional drug discovery routes are inefficient. The best alternative strategies to overcome these challenges might include exploring new bacterial pathways, utilizing compounds with antibacterial activities from the human microbiome, and repurposing existing drugs. Moreover, novel drug delivery mechanisms that leverage, for example, nanotechnology-based carriers may be breakthrough ideas that can increase antibiotic efficacy and, at the same time, reduce toxicity. Current clinical trials of next-generation drugs indicate that some treatments possess excellent potential to overcome the MDR issue. Conclusion: Despite the substantial obstacles to getting bench findings to the patient, numerous scientists are still working towards this goal. Both the application of antibiotic stewardship principles and timely considerations through the regulatory pathways are needed to release the next generation of antibiotics that are suitable for the fight against superbugs.
| Original language | English |
|---|---|
| Pages (from-to) | 859-889 |
| Journal | Pharmaceutical Research |
| Volume | 42 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 16 Jun 2025 |
| MoE publication type | A2 Review article in a scientific journal |
Funding
Open access funding provided by Åbo Akademi University. This research was funded by the Swedish Cultural Foundation, grant numbers 190913 (FH) and 188147 (IA) and the SÅA-funded CoE “Materials-driven solutions for combating antimicrobial resistance" (MADNESS). Open access funding provided by Åbo Akademi University. This research was funded by the Swedish Cultural Foundation, grant numbers 190913 (FH) and 188147 (IA) and the SÅA-funded CoE “Materials-driven solutions for combating antimicrobial resistance" (MADNESS). This work is part of the activities of the Åbo Akademi University Foundation (SÅA) funded Centre of Excellence in Research “Materials-driven solutions for combating antimicrobial resistance (MADNESS)” and aligned with the activities of the strategic research profiling area “Solutions for Health” at Åbo Akademi University [Research Council/Academy of Finland, # 336355].
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being -
SDG 11 Sustainable Cities and Communities -
SDG 12 Responsible Consumption and Production
Fingerprint
Dive into the research topics of 'The Next Frontier: Unveiling Novel Approaches for Combating Multidrug-Resistant Bacteria'. Together they form a unique fingerprint.Projects
- 1 Active
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MADNESS: Centre of Excellence in Materials-driven solutions for combatting antimicrobial resistance
Rosenholm, J. (Principal Investigator), Porres Paltor, I. (Co-Principal Investigator), Bansal, K. (Coordinator), Lafond, S. (Co-Principal Investigator), Uppstu, P. (Co-Principal Investigator), Viitala, T. (Co-Principal Investigator), Wang, X. (Co-Principal Investigator), Wilen, C.-E. (Co-Principal Investigator), Xu, C. (Co-Principal Investigator), Zhang, H. (Co-Principal Investigator), Lu, Z. (Co-Investigator), Verma, J. (Co-Investigator), Kumar, V. (Co-Investigator), Frejborg, F. (Co-Investigator), Wang, S. (Co-Investigator), Ran, M. (Co-Investigator), Ma, X. (Co-Investigator), Yang, W. (Co-Investigator), Liang, S. (Co-Investigator), Zhang, Y. (Co-Investigator), Fan, L. (Co-Investigator), Chen, Y. (Co-Investigator), Wang, L. (Co-Investigator), Zhuang, P. (Co-Investigator), Rajan Prakash, D. (Co-Investigator), Howaili, F. (Co-Investigator), Gulshan, R. (Co-Investigator), Yadav, D. (Co-Investigator), Pathak, C. (Co-Investigator), Mustafa, R. (Co-Investigator), DarzianRostami, L. (Co-Investigator), Jafari Dargahlou, M. (Co-Investigator), Nygård, A. (Co-Investigator), Samrat, S. R. (Co-Investigator) & Rexha, H. (Co-Investigator)
01/01/24 → 31/12/28
Project: Foundation
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