Targeting the cannabinoid CB2 receptor: mutations, modeling and development of CB2 selective ligands

Raitio, Outi Salo-Ahen, Nevalainen, Poso, Järvinen

    Research output: Contribution to journalReview Article or Literature Reviewpeer-review

    63 Citations (Scopus)


    Since the discovery of the cannabinoid CB2 receptor in 1993, there has been a growing interest to clarify the importance of this G-protein coupled receptor (GPCR) for human physiology, and to investigate it as a possible target for current and future drug development. Several mutation studies have examined the receptor activation and structure of the receptor binding cavity. Additionally, 3D models for the CB2 receptor have been constructed to aid in perceiving important ligand-receptor interactions. In recent years, many research groups have succeeded in synthesizing new CB2 selective ligands. This review focuses on (i) important features for ligand recognition and/or receptor activation at CB2, derived from mutation and modeling studies, and (ii) recent advances in the field of CB2 selective ligands.
    Original languageUndefined/Unknown
    Pages (from-to)1217–1237
    JournalCurrent Medicinal Chemistry
    Issue number10
    Publication statusPublished - 2005
    MoE publication typeA2 Review article in a scientific journal

    Cite this