Targeted intracellular delivery of hydrophobic agents using mesoporous hybrid silica nanoparticles as carrier systems

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    Abstract

    Targeted nanoparticle-mediated intracellular delivery is demonstrated using two hydrophobic fluorophores as model drug cargo. The presented hybrid carrier system exhibits both cancer cell-targeting ability and capacity to retain a hydrophobic agent with subsequent specific release into the endosomal compartment. Furthermore, the incorporated agent is shown to be able to escape from the endosomes into the cytoplasm, making the particles promising candidates as carriers for targeted drug delivery for cancer treatment.
    Original languageUndefined/Unknown
    Pages (from-to)3308–3311
    JournalNano Letters
    Volume9
    Issue number9
    DOIs
    Publication statusPublished - 2009
    MoE publication typeA1 Journal article-refereed

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