Tailoring of Proteostasis Networks with Heat Shock Factors

Jenny Joutsen, Lea Sistonen

Research output: Contribution to journalReview Article or Literature Reviewpeer-review


Heat shock factors (HSFs) are the main transcriptional regulators of the heat shock response and indispensable for maintaining cellular proteostasis. HSFs mediate their protective functions through diverse genetic programs, which are composed of genes encoding molecular chaperones and other genes crucial for cell survival. The mechanisms that are used to tailor HSF-driven proteostasis networks are not yet completely understood, but they likely comprise from distinct combinations of both genetic and proteomic determinants. In this review, we highlight the versatile HSF-mediated cellular functions that extend from cellular stress responses to various physiological and pathological processes, and we underline the key advancements that have been achieved in the field of HSF research during the last decade.

Original languageEnglish
JournalCold Spring Harbor Perspectives in Biology
Issue number4
Publication statusPublished - 1 Apr 2019
MoE publication typeA2 Review article in a scientific journal


  • Animals
  • Heat Shock Transcription Factors/chemistry
  • Humans
  • Protein Conformation
  • Protein Processing, Post-Translational
  • Proteostasis


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