Spirocycles, including spirocyclic ethers, occur frequently in natural products and pharmaceutically active substances. Accordingly, synthetic methodologies utilized for the preparation of such compounds are of broad interest. The present review focuses on the general synthetic approaches that have been utilized for the construction of spirocyclic ethers during the past two decades.
|Number of pages||23|
|Publication status||Published - 2009|
|MoE publication type||A2 Review article in a scientific journal|
- natural products
- ring closure
- spiro compounds
- stereoselective synthesis