Synthesis and preclinical characterization of [Cu-64]NODAGA-MAL-exendin-4 with a N-epsilon-maleoyl-L-lysyl-glycine linkage

Cheng-Bin Yim; Kirsi Mikkola; Veronica Fagerholm; Viki-Veikko Elomaa; Tamiko Ishizu; Johan Rajander; Joern Schlesinger; Anne Roivainen; Pirjo Nuutila; Olof Solin

doi:10.1016/j.nucmedbio.2013.06.012

Synthesis and preclinical characterization of [Cu-64]NODAGA-MAL-exendin-4 with a N-epsilon-maleoyl-L-lysyl-glycine linkage

Cheng-Bin Yim, Kirsi Mikkola, Veronica Fagerholm, Viki-Veikko Elomaa, Tamiko Ishizu, Johan Rajander, Joern Schlesinger, Anne Roivainen, Pirjo Nuutila, Olof Solin

Research output: Contribution to journal › Article › Scientific › peer-review

25 Citations (Scopus)

Abstract

Conclusions: The incorporated MAL linkage in [Cu-64]NODAGA-MAL-exendin-4 was unable to reduce kidney radioactivity levels, compared to [Cu-64]NODAGA-exendin-4. The applicability of metabolizable linkages in the design of kidney-saving exendin-4 analogs requires further investigation. (C) 2013 Elsevier Inc. All rights reserved.

Original language	Undefined/Unknown
Pages (from-to)	1006–1012
Number of pages	7
Journal	Nuclear Medicine and Biology
Volume	40
Issue number	8
DOIs	https://doi.org/10.1016/j.nucmedbio.2013.06.012
Publication status	Published - 2013
MoE publication type	A1 Journal article-refereed

Keywords

Copper-64
Exendin
GLP-1 receptor
NODAGA
Renal brush border membrane

Access to Document

10.1016/j.nucmedbio.2013.06.012

Cite this

@article{933c4246ad9e409f825afabae29a235d,

title = "Synthesis and preclinical characterization of [Cu-64]NODAGA-MAL-exendin-4 with a N-epsilon-maleoyl-L-lysyl-glycine linkage",

abstract = "Conclusions: The incorporated MAL linkage in [Cu-64]NODAGA-MAL-exendin-4 was unable to reduce kidney radioactivity levels, compared to [Cu-64]NODAGA-exendin-4. The applicability of metabolizable linkages in the design of kidney-saving exendin-4 analogs requires further investigation. (C) 2013 Elsevier Inc. All rights reserved.",

keywords = "Copper-64, Exendin, GLP-1 receptor, NODAGA, Renal brush border membrane, Copper-64, Exendin, GLP-1 receptor, NODAGA, Renal brush border membrane, Copper-64, Exendin, GLP-1 receptor, NODAGA, Renal brush border membrane",

author = "Cheng-Bin Yim and Kirsi Mikkola and Veronica Fagerholm and Viki-Veikko Elomaa and Tamiko Ishizu and Johan Rajander and Joern Schlesinger and Anne Roivainen and Pirjo Nuutila and Olof Solin",

year = "2013",

doi = "10.1016/j.nucmedbio.2013.06.012",

language = "Odefinierat/ok{\"a}nt",

volume = "40",

pages = "1006–1012",

journal = "Nuclear Medicine and Biology",

issn = "0969-8051",

publisher = "Elsevier",

number = "8",

}

TY - JOUR

T1 - Synthesis and preclinical characterization of [Cu-64]NODAGA-MAL-exendin-4 with a N-epsilon-maleoyl-L-lysyl-glycine linkage

AU - Yim, Cheng-Bin

AU - Mikkola, Kirsi

AU - Fagerholm, Veronica

AU - Elomaa, Viki-Veikko

AU - Ishizu, Tamiko

AU - Rajander, Johan

AU - Schlesinger, Joern

AU - Roivainen, Anne

AU - Nuutila, Pirjo

AU - Solin, Olof

PY - 2013

Y1 - 2013

N2 - Conclusions: The incorporated MAL linkage in [Cu-64]NODAGA-MAL-exendin-4 was unable to reduce kidney radioactivity levels, compared to [Cu-64]NODAGA-exendin-4. The applicability of metabolizable linkages in the design of kidney-saving exendin-4 analogs requires further investigation. (C) 2013 Elsevier Inc. All rights reserved.

AB - Conclusions: The incorporated MAL linkage in [Cu-64]NODAGA-MAL-exendin-4 was unable to reduce kidney radioactivity levels, compared to [Cu-64]NODAGA-exendin-4. The applicability of metabolizable linkages in the design of kidney-saving exendin-4 analogs requires further investigation. (C) 2013 Elsevier Inc. All rights reserved.

KW - Copper-64

KW - Exendin

KW - GLP-1 receptor

KW - NODAGA

KW - Renal brush border membrane

KW - Copper-64

KW - Exendin

KW - GLP-1 receptor

KW - NODAGA

KW - Renal brush border membrane

KW - Copper-64

KW - Exendin

KW - GLP-1 receptor

KW - NODAGA

KW - Renal brush border membrane

U2 - 10.1016/j.nucmedbio.2013.06.012

DO - 10.1016/j.nucmedbio.2013.06.012

M3 - Artikel

SN - 0969-8051

VL - 40

SP - 1006

EP - 1012

JO - Nuclear Medicine and Biology

JF - Nuclear Medicine and Biology

IS - 8

ER -