Synthesis and preclinical characterization of [Cu-64]NODAGA-MAL-exendin-4 with a N-epsilon-maleoyl-L-lysyl-glycine linkage

Cheng-Bin Yim, Kirsi Mikkola, Veronica Fagerholm, Viki-Veikko Elomaa, Tamiko Ishizu, Johan Rajander, Joern Schlesinger, Anne Roivainen, Pirjo Nuutila, Olof Solin

    Research output: Contribution to journalArticleScientificpeer-review

    14 Citations (Scopus)

    Abstract

    Conclusions: The incorporated MAL linkage in [Cu-64]NODAGA-MAL-exendin-4 was unable to reduce kidney radioactivity levels, compared to [Cu-64]NODAGA-exendin-4. The applicability of metabolizable linkages in the design of kidney-saving exendin-4 analogs requires further investigation. (C) 2013 Elsevier Inc. All rights reserved.
    Original languageUndefined/Unknown
    Pages (from-to)1006–1012
    Number of pages7
    JournalNuclear Medicine and Biology
    Volume40
    Issue number8
    DOIs
    Publication statusPublished - 2013
    MoE publication typeA1 Journal article-refereed

    Keywords

    • Copper-64
    • Exendin
    • GLP-1 receptor
    • NODAGA
    • Renal brush border membrane

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