Abstract
Acemetacin (ACM), a carboxymethyl ester of indomethacin, is a potent anti-inflammatory drug. However, the low solubility and is easily degraded in the stomach causes gastric mucosal dysfunction. This study. Aimed to synthetize a Janus dendrimer with polyesters, which are strong protection of the acemetacin for an efficient delivery in the targets. The dendrons with two or four acemetacin molecules were attached via azido-alkyne Click reaction to obtain the Janus dendrimers. The rates of hydrolysis at stomach conditions pH 1.4 at 37 °C showed that dendrons and Janus dendrimers are constant at different times. Janus dendrimers showed good activity against three human cells: Chronic myelogenous leukemia, mammary adenocarcinoma and lung adenocarcinoma cancer cells. The dendrons and dendrimers do not show activity against normal cells. Our study comprehensively demonstrates the advantages of polyester Janus dendrimers acemetacin delivery platform and that acemetacin conjugated with polyesters can act as anticancer agent.
| Original language | English |
|---|---|
| Pages (from-to) | 3160-3170 |
| Number of pages | 11 |
| Journal | Journal of Materials Research |
| Volume | 40 |
| Issue number | 22 |
| DOIs | |
| Publication status | Published - 28 Nov 2025 |
| MoE publication type | A1 Journal article-refereed |
Funding
This research was funded by DGAPA, grant number IN205123 and IBM and AEH were supported by a doctoral and master fellowship from CONAHCyT. We would like to thank Huerta S. E., Peña González M. A., Rios Ruiz L. M., García Rios., Orta-Pérez Ma. E., Romo Pérez A., Quiroz García B., and Márquez Alonso M. del C., for technical assistance.
Keywords
- Acemetacin
- Anticancer activity
- Click reaction
- Poli(ester)
Fingerprint
Dive into the research topics of 'Synthesis and anticancer activity of poly(ester) acemetacin conjugates'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver