Synthesis and analytical characterization of monomeric N-oxidized derivatives of α-tocopheramine

Anjan Patel, Andreas Hofinger, Thomas Rosenau*

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

2 Citations (Scopus)


α-Tocopheramine has shown great promises as a stabilizer for synthetic and natural polymers, but is also investigated in various biomedical scenarios. Many studies have been hampered by the fact that the oxidation products of α-tocopheramine have not yet been properly identified and their analytical data are still lacking. In the present study, we synthesized and fully analytically characterized all N-oxidation products that can form upon oxidation of α-tocopheramine in aqueous media, including the hydroxylamine, nitroso, and nitro derivative, in this way providing standards for the identification of the so far elusive byproducts. Synthesis and stability of the derivatives are discussed. Graphic abstract: [Figure not available: see fulltext.].

Original languageEnglish
Pages (from-to)959-966
Number of pages8
JournalMonatshefte fur Chemie
Issue number8
Publication statusPublished - Aug 2021
MoE publication typeA1 Journal article-refereed


  • ortho-Quinone methide
  • Oxidation
  • Reduction
  • Tocopheramine
  • Vitamin E


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