Studying Nestin and its Interrelationship with Cdk5

Julia Lindqvist, Num Vistbacka, John Eriksson, M. Bishr Omary (Editor), Ronald K.H. Liem (Editor)

Research output: Contribution to journalArticleScientificpeer-review

10 Citations (Scopus)

Abstract

Current research utilizes the specific expression pattern of intermediate filaments (IF) for identifying cellular state and origin, as well as for the purpose of disease diagnosis. Nestin is commonly utilized as a specific marker and driver for CNS progenitor cell types, but in addition, nestin can be found in several mesenchymal progenitor cells, and it is constitutively expressed in a few restricted locations, such as muscle neuromuscular junctions and kidney podocytes. Alike most other members of the IF protein family, nestin filaments are dynamic, constantly being remodeled through posttranslational modifications, which alter the solubility, protein levels, and signaling capacity of the nestin filaments. Through its interactions with kinases and other signaling executors, resulting in a complex and bidirectional regulation of cell signaling events, nestin has the potential to determine whether cells divide, differentiate, migrate, or stay in place. In this review, the broad and similar roles of IFs as dynamic signaling scaffolds, is exemplified by observations of nestin functions and its interaction with the cyclin- dependent kinase 5, the atypical kinase in the family of cyclin-dependent kinases.

Original languageUndefined/Unknown
Pages (from-to)509–535
JournalMethods in Enzymology
Volume568
Publication statusPublished - 2016
MoE publication typeA1 Journal article-refereed

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