Structural Investigation of Biologically Active Phenolic Compounds Isolated from European Tree Species

Izabela Redzynia, Natasza E. Ziólkowska, Wieslaw R. Majzner, Stefan Willför, Rainer Sjöholm, Patrik Christoffer Eklund, Grzegorz Bujacz

    Research output: Contribution to journalArticleScientificpeer-review

    9 Citations (Scopus)

    Abstract

    X-ray structures of two compounds isolated from wood knots of coniferous trees, namely dihydrokaempferol (3,5,8,13-tetrahydroxyflavanon) and lariciresinol (3,14-dimetoxy-7,10-epoxylignan-4,15,19-triol), are presented here. Diffraction data for the dihydrokaempferol crystals were collected on a CAD4 diffractometer and on a synchrotron for the lariciresinol crystal. The investigated compounds inhibit lipid peroxidation and lariciresinol is additionally a good scavenger of superoxide radicals. The structural data presented in this work provide a useful basis for designing more active compounds with potential use as antioxidants.
    Original languageUndefined/Unknown
    Pages (from-to)4147–4158
    Number of pages12
    JournalMolecules
    Volume14
    Issue number10
    DOIs
    Publication statusPublished - 2009
    MoE publication typeA1 Journal article-refereed

    Keywords

    • "host - guest" inclusion crystals
    • antioxidant potency
    • crystal structure
    • flavonoids
    • lignans
    • phenolic compounds

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