Structural Investigation of Biologically Active Phenolic Compounds Isolated from European Tree Species

Izabela Redzynia; Natasza E. Ziólkowska; Wieslaw R. Majzner; Stefan Willför; Rainer Sjöholm; Patrik Christoffer Eklund; Grzegorz Bujacz

doi:10.3390/molecules14104147

Structural Investigation of Biologically Active Phenolic Compounds Isolated from European Tree Species

Izabela Redzynia, Natasza E. Ziólkowska, Wieslaw R. Majzner, Stefan Willför, Rainer Sjöholm, Patrik Christoffer Eklund, Grzegorz Bujacz

Research output: Contribution to journal › Article › Scientific › peer-review

11 Citations (Scopus)

Abstract

X-ray structures of two compounds isolated from wood knots of coniferous trees, namely dihydrokaempferol (3,5,8,13-tetrahydroxyflavanon) and lariciresinol (3,14-dimetoxy-7,10-epoxylignan-4,15,19-triol), are presented here. Diffraction data for the dihydrokaempferol crystals were collected on a CAD4 diffractometer and on a synchrotron for the lariciresinol crystal. The investigated compounds inhibit lipid peroxidation and lariciresinol is additionally a good scavenger of superoxide radicals. The structural data presented in this work provide a useful basis for designing more active compounds with potential use as antioxidants.

Original language	Undefined/Unknown
Pages (from-to)	4147–4158
Number of pages	12
Journal	Molecules
Volume	14
Issue number	10
DOIs	https://doi.org/10.3390/molecules14104147
Publication status	Published - 2009
MoE publication type	A1 Journal article-refereed

Keywords

"host - guest" inclusion crystals
antioxidant potency
crystal structure
flavonoids
lignans
phenolic compounds

Access to Document

10.3390/molecules14104147

Cite this

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title = "Structural Investigation of Biologically Active Phenolic Compounds Isolated from European Tree Species",

abstract = "X-ray structures of two compounds isolated from wood knots of coniferous trees, namely dihydrokaempferol (3,5,8,13-tetrahydroxyflavanon) and lariciresinol (3,14-dimetoxy-7,10-epoxylignan-4,15,19-triol), are presented here. Diffraction data for the dihydrokaempferol crystals were collected on a CAD4 diffractometer and on a synchrotron for the lariciresinol crystal. The investigated compounds inhibit lipid peroxidation and lariciresinol is additionally a good scavenger of superoxide radicals. The structural data presented in this work provide a useful basis for designing more active compounds with potential use as antioxidants.",

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author = "Izabela Redzynia and Zi{\'o}lkowska, {Natasza E.} and Majzner, {Wieslaw R.} and Stefan Willf{\"o}r and Rainer Sj{\"o}holm and Eklund, {Patrik Christoffer} and Grzegorz Bujacz",

year = "2009",

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T1 - Structural Investigation of Biologically Active Phenolic Compounds Isolated from European Tree Species

AU - Redzynia, Izabela

AU - Ziólkowska, Natasza E.

AU - Majzner, Wieslaw R.

AU - Willför, Stefan

AU - Sjöholm, Rainer

AU - Eklund, Patrik Christoffer

AU - Bujacz, Grzegorz

PY - 2009

Y1 - 2009

N2 - X-ray structures of two compounds isolated from wood knots of coniferous trees, namely dihydrokaempferol (3,5,8,13-tetrahydroxyflavanon) and lariciresinol (3,14-dimetoxy-7,10-epoxylignan-4,15,19-triol), are presented here. Diffraction data for the dihydrokaempferol crystals were collected on a CAD4 diffractometer and on a synchrotron for the lariciresinol crystal. The investigated compounds inhibit lipid peroxidation and lariciresinol is additionally a good scavenger of superoxide radicals. The structural data presented in this work provide a useful basis for designing more active compounds with potential use as antioxidants.

AB - X-ray structures of two compounds isolated from wood knots of coniferous trees, namely dihydrokaempferol (3,5,8,13-tetrahydroxyflavanon) and lariciresinol (3,14-dimetoxy-7,10-epoxylignan-4,15,19-triol), are presented here. Diffraction data for the dihydrokaempferol crystals were collected on a CAD4 diffractometer and on a synchrotron for the lariciresinol crystal. The investigated compounds inhibit lipid peroxidation and lariciresinol is additionally a good scavenger of superoxide radicals. The structural data presented in this work provide a useful basis for designing more active compounds with potential use as antioxidants.

KW - "host - guest" inclusion crystals

KW - antioxidant potency

KW - crystal structure

KW - flavonoids

KW - lignans

KW - phenolic compounds

KW - "host - guest" inclusion crystals

KW - antioxidant potency

KW - crystal structure

KW - flavonoids

KW - lignans

KW - phenolic compounds

KW - "host - guest" inclusion crystals

KW - antioxidant potency

KW - crystal structure

KW - flavonoids

KW - lignans

KW - phenolic compounds

U2 - 10.3390/molecules14104147

DO - 10.3390/molecules14104147

M3 - Artikel

SN - 1420-3049

VL - 14

SP - 4147

EP - 4158

JO - Molecules

JF - Molecules

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