TY - JOUR
T1 - Sphingolipid-mediated calcium signaling and its pathological effects.
AU - Pulli, Ilari
AU - Asghar, Muhammad Yasir
AU - Kemppainen, Kati
AU - Törnquist, Kid
PY - 2018
Y1 - 2018
N2 - Metabolites of sphingomyelin, as well as calcium ion fluxes, have a profound role in cellular signaling in almost all cell types. In addition, metabolites of sphingomyelin often modulate calcium signaling, either directly or indirectly. This is an interesting aspect on how lipids may wield their physiological role, as calcium is probably one of the most versatile signaling molecules in the cell, and as modulation of calcium signaling has profound effects on cellular physiology. The aim of this review is to discuss the mechanisms by which metabolites of sphingomyelin, especially the sphingolipids sphingosine and sphingosine 1-phosphate (S1P), modulate calcium fluxes, and how this may affect cellular function. In addition, the pathological aspects of sphingolipid-evoked modulation of calcium fluxes will be discussed.
AB - Metabolites of sphingomyelin, as well as calcium ion fluxes, have a profound role in cellular signaling in almost all cell types. In addition, metabolites of sphingomyelin often modulate calcium signaling, either directly or indirectly. This is an interesting aspect on how lipids may wield their physiological role, as calcium is probably one of the most versatile signaling molecules in the cell, and as modulation of calcium signaling has profound effects on cellular physiology. The aim of this review is to discuss the mechanisms by which metabolites of sphingomyelin, especially the sphingolipids sphingosine and sphingosine 1-phosphate (S1P), modulate calcium fluxes, and how this may affect cellular function. In addition, the pathological aspects of sphingolipid-evoked modulation of calcium fluxes will be discussed.
KW - Signaling: receptors
KW - Sphingosine 1-phosphate
KW - sphingolipids
KW - Signaling: receptors
KW - Sphingosine 1-phosphate
KW - sphingolipids
KW - Signaling: receptors
KW - Sphingosine 1-phosphate
KW - sphingolipids
U2 - 10.1016/j.bbamcr.2018.04.012
DO - 10.1016/j.bbamcr.2018.04.012
M3 - Artikel
SN - 0006-3002
VL - 1865
SP - 1668
EP - 1677
JO - BBA - Biochimica et Biophysica Acta
JF - BBA - Biochimica et Biophysica Acta
IS - 11 B
ER -