Sphingolipid-mediated calcium signaling and its pathological effects.

Ilari Pulli; Muhammad Yasir Asghar; Kati Kemppainen; Kid Törnquist

doi:10.1016/j.bbamcr.2018.04.012

Sphingolipid-mediated calcium signaling and its pathological effects.

Ilari Pulli, Muhammad Yasir Asghar, Kati Kemppainen, Kid Törnquist

Research output: Contribution to journal › Article › Scientific › peer-review

32 Citations (Scopus)

Abstract

Metabolites of sphingomyelin, as well as calcium ion fluxes, have a profound role in cellular signaling in almost all cell types. In addition, metabolites of sphingomyelin often modulate calcium signaling, either directly or indirectly. This is an interesting aspect on how lipids may wield their physiological role, as calcium is probably one of the most versatile signaling molecules in the cell, and as modulation of calcium signaling has profound effects on cellular physiology. The aim of this review is to discuss the mechanisms by which metabolites of sphingomyelin, especially the sphingolipids sphingosine and sphingosine 1-phosphate (S1P), modulate calcium fluxes, and how this may affect cellular function. In addition, the pathological aspects of sphingolipid-evoked modulation of calcium fluxes will be discussed.

Original language	Undefined/Unknown
Pages (from-to)	1668–1677
Journal	BBA - Biochimica et Biophysica Acta
Volume	1865
Issue number	11 B
DOIs	https://doi.org/10.1016/j.bbamcr.2018.04.012
Publication status	Published - 2018
MoE publication type	A1 Journal article-refereed

Keywords

Signaling: receptors
Sphingosine 1-phosphate
sphingolipids

Access to Document

10.1016/j.bbamcr.2018.04.012

Cite this

@article{b4201b1d180f4eadbc02897d54c87805,

title = "Sphingolipid-mediated calcium signaling and its pathological effects.",

abstract = "Metabolites of sphingomyelin, as well as calcium ion fluxes, have a profound role in cellular signaling in almost all cell types. In addition, metabolites of sphingomyelin often modulate calcium signaling, either directly or indirectly. This is an interesting aspect on how lipids may wield their physiological role, as calcium is probably one of the most versatile signaling molecules in the cell, and as modulation of calcium signaling has profound effects on cellular physiology. The aim of this review is to discuss the mechanisms by which metabolites of sphingomyelin, especially the sphingolipids sphingosine and sphingosine 1-phosphate (S1P), modulate calcium fluxes, and how this may affect cellular function. In addition, the pathological aspects of sphingolipid-evoked modulation of calcium fluxes will be discussed.",

keywords = "Signaling: receptors, Sphingosine 1-phosphate, sphingolipids, Signaling: receptors, Sphingosine 1-phosphate, sphingolipids, Signaling: receptors, Sphingosine 1-phosphate, sphingolipids",

author = "Ilari Pulli and Asghar, {Muhammad Yasir} and Kati Kemppainen and Kid T{\"o}rnquist",

year = "2018",

doi = "10.1016/j.bbamcr.2018.04.012",

language = "Odefinierat/ok{\"a}nt",

volume = "1865",

pages = "1668–1677",

journal = "BBA - Biochimica et Biophysica Acta",

issn = "0006-3002",

publisher = "Elsevier",

number = "11 B",

}

TY - JOUR

T1 - Sphingolipid-mediated calcium signaling and its pathological effects.

AU - Pulli, Ilari

AU - Asghar, Muhammad Yasir

AU - Kemppainen, Kati

AU - Törnquist, Kid

PY - 2018

Y1 - 2018

N2 - Metabolites of sphingomyelin, as well as calcium ion fluxes, have a profound role in cellular signaling in almost all cell types. In addition, metabolites of sphingomyelin often modulate calcium signaling, either directly or indirectly. This is an interesting aspect on how lipids may wield their physiological role, as calcium is probably one of the most versatile signaling molecules in the cell, and as modulation of calcium signaling has profound effects on cellular physiology. The aim of this review is to discuss the mechanisms by which metabolites of sphingomyelin, especially the sphingolipids sphingosine and sphingosine 1-phosphate (S1P), modulate calcium fluxes, and how this may affect cellular function. In addition, the pathological aspects of sphingolipid-evoked modulation of calcium fluxes will be discussed.

AB - Metabolites of sphingomyelin, as well as calcium ion fluxes, have a profound role in cellular signaling in almost all cell types. In addition, metabolites of sphingomyelin often modulate calcium signaling, either directly or indirectly. This is an interesting aspect on how lipids may wield their physiological role, as calcium is probably one of the most versatile signaling molecules in the cell, and as modulation of calcium signaling has profound effects on cellular physiology. The aim of this review is to discuss the mechanisms by which metabolites of sphingomyelin, especially the sphingolipids sphingosine and sphingosine 1-phosphate (S1P), modulate calcium fluxes, and how this may affect cellular function. In addition, the pathological aspects of sphingolipid-evoked modulation of calcium fluxes will be discussed.

KW - Signaling: receptors

KW - Sphingosine 1-phosphate

KW - sphingolipids

KW - Signaling: receptors

KW - Sphingosine 1-phosphate

KW - sphingolipids

KW - Signaling: receptors

KW - Sphingosine 1-phosphate

KW - sphingolipids

U2 - 10.1016/j.bbamcr.2018.04.012

DO - 10.1016/j.bbamcr.2018.04.012

M3 - Artikel

SN - 0006-3002

VL - 1865

SP - 1668

EP - 1677

JO - BBA - Biochimica et Biophysica Acta

JF - BBA - Biochimica et Biophysica Acta

IS - 11 B

ER -