Solvent and surfactant induced interactions in drug dispersions

Jarl B. Rosenholm

doi:10.1016/j.colsurfa.2009.10.009

Solvent and surfactant induced interactions in drug dispersions

Jarl B. Rosenholm^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

13 Citations (Scopus)

Abstract

The interaction between Salbutamol base and Salbutamol sulphate drug particles with a number of non-aqueous and mixed liquids is investigated. The non-aqueous liquids extend form hydrocarbon to halo-hydrocarbon liquids, including propellant liquids previously used in Metered Dose Inhalers. The properties are correlated using two commonly used solvent scales, the Hamaker constant and Solubility parameter scales. The focus is laid on evaluating their relationship to the effective surface charge (ζ-potential), the particle size and their capability to predict the solubility of the drugs. The influence of a standard surfactant, oleic acid on the chosen properties is another topic of key interest. The stability of the dispersions was successfully predicted by the Coulomb interaction model of Morris.

Original language	English
Pages (from-to)	197-204
Number of pages	8
Journal	Colloids and Surfaces A: Physicochemical and Engineering Aspects
Volume	354
Issue number	1-3
DOIs	https://doi.org/10.1016/j.colsurfa.2009.10.009
Publication status	Published - 5 Feb 2010
MoE publication type	A1 Journal article-refereed

Keywords

Dispersion stability
Halogenated hydrocarbons
Hamaker constant
Hydrocarbons
Particle size
Propellant liquids
Salbutamol base
Salbutamol sulphate
Solubility
Solubility parameter
ζ-Potential

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10.1016/j.colsurfa.2009.10.009

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@article{f820d80c35d64649acf8f644014c70b7,

title = "Solvent and surfactant induced interactions in drug dispersions",

abstract = "The interaction between Salbutamol base and Salbutamol sulphate drug particles with a number of non-aqueous and mixed liquids is investigated. The non-aqueous liquids extend form hydrocarbon to halo-hydrocarbon liquids, including propellant liquids previously used in Metered Dose Inhalers. The properties are correlated using two commonly used solvent scales, the Hamaker constant and Solubility parameter scales. The focus is laid on evaluating their relationship to the effective surface charge (ζ-potential), the particle size and their capability to predict the solubility of the drugs. The influence of a standard surfactant, oleic acid on the chosen properties is another topic of key interest. The stability of the dispersions was successfully predicted by the Coulomb interaction model of Morris.",

keywords = "Dispersion stability, Halogenated hydrocarbons, Hamaker constant, Hydrocarbons, Particle size, Propellant liquids, Salbutamol base, Salbutamol sulphate, Solubility, Solubility parameter, ζ-Potential",

author = "Rosenholm, {Jarl B.}",

note = "Funding Information: Mr. Pasi Mikkola, MSc is thanked for providing some of the experimental results. The National Funding Agency for Technology and Innovation (TEKES) is thanked for funding. ",

year = "2010",

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day = "5",

doi = "10.1016/j.colsurfa.2009.10.009",

language = "English",

volume = "354",

pages = "197--204",

journal = "Colloids and Surfaces A: Physicochemical and Engineering Aspects",

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publisher = "Elsevier",

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TY - JOUR

T1 - Solvent and surfactant induced interactions in drug dispersions

AU - Rosenholm, Jarl B.

N1 - Funding Information: Mr. Pasi Mikkola, MSc is thanked for providing some of the experimental results. The National Funding Agency for Technology and Innovation (TEKES) is thanked for funding.

PY - 2010/2/5

Y1 - 2010/2/5

N2 - The interaction between Salbutamol base and Salbutamol sulphate drug particles with a number of non-aqueous and mixed liquids is investigated. The non-aqueous liquids extend form hydrocarbon to halo-hydrocarbon liquids, including propellant liquids previously used in Metered Dose Inhalers. The properties are correlated using two commonly used solvent scales, the Hamaker constant and Solubility parameter scales. The focus is laid on evaluating their relationship to the effective surface charge (ζ-potential), the particle size and their capability to predict the solubility of the drugs. The influence of a standard surfactant, oleic acid on the chosen properties is another topic of key interest. The stability of the dispersions was successfully predicted by the Coulomb interaction model of Morris.

AB - The interaction between Salbutamol base and Salbutamol sulphate drug particles with a number of non-aqueous and mixed liquids is investigated. The non-aqueous liquids extend form hydrocarbon to halo-hydrocarbon liquids, including propellant liquids previously used in Metered Dose Inhalers. The properties are correlated using two commonly used solvent scales, the Hamaker constant and Solubility parameter scales. The focus is laid on evaluating their relationship to the effective surface charge (ζ-potential), the particle size and their capability to predict the solubility of the drugs. The influence of a standard surfactant, oleic acid on the chosen properties is another topic of key interest. The stability of the dispersions was successfully predicted by the Coulomb interaction model of Morris.

KW - Dispersion stability

KW - Halogenated hydrocarbons

KW - Hamaker constant

KW - Hydrocarbons

KW - Particle size

KW - Propellant liquids

KW - Salbutamol base

KW - Salbutamol sulphate

KW - Solubility

KW - Solubility parameter

KW - ζ-Potential

UR - http://www.scopus.com/inward/record.url?scp=73049113085&partnerID=8YFLogxK

U2 - 10.1016/j.colsurfa.2009.10.009

DO - 10.1016/j.colsurfa.2009.10.009

M3 - Article

AN - SCOPUS:73049113085

SN - 0927-7757

VL - 354

SP - 197

EP - 204

JO - Colloids and Surfaces A: Physicochemical and Engineering Aspects

JF - Colloids and Surfaces A: Physicochemical and Engineering Aspects

IS - 1-3

ER -

Solvent and surfactant induced interactions in drug dispersions

Abstract

Keywords

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