SHARPIN regulates collagen architecture and ductal outgrowth in the developing mouse mammary gland.

Peuhu, Kaukonen, Lerche, Saari, Guzmán, Rantakari, De Franceschi, Wärri, Georgiadou, Guillaume Jacquemet, Mattila, Virtakoivu, Liu, Attieh, Silva, Sundberg, Betz, Deugnier, Salmi, IvaskaEliceiri

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Abstract

mammary gland stromal fibroblasts demonstrated defects in collagen fibre assembly, collagen contraction and degradation in vitro Together, these data imply that SHARPIN regulates the normal invasive mammary gland branching morphogenesis in an epithelial cell extrinsic manner by controlling the organisation of the stromal ECM.
Original languageUndefined/Unknown
Pages (from-to)165–182
JournalEMBO Journal
Volume36
Issue number2
DOIs
Publication statusPublished - 2017
MoE publication typeA1 Journal article-refereed

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