Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy

Jiaqi Yan; Haixia Zou; Wenhui Zhou; Xiaowan Yuan; Zhijun Li; Xiaodong Ma; Chang Liu; Yonghui Wang; Jessica M. Rosenholm; Wenguo Cui; Xiangmeng Qu; Hongbo Zhang

doi:10.1039/D2BM00640E

Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy

Jiaqi Yan, Haixia Zou, Wenhui Zhou, Xiaowan Yuan, Zhijun Li, Xiaodong Ma, Chang Liu, Yonghui Wang, Jessica M. Rosenholm, Wenguo Cui, Xiangmeng Qu, Hongbo Zhang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

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Abstract

Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.

Original language	English
Pages (from-to)	4119-4125
Number of pages	7
Journal	Biomaterials Science
Volume	10
Issue number	15
DOIs	https://doi.org/10.1039/D2BM00640E
Publication status	Published - 20 Jun 2022
MoE publication type	A1 Journal article-refereed

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10.1039/D2BM00640ELicence: CC BY

Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy 2022Final published version, 2.44 MBLicence: CC BY

Åbo Akademi Functional Printing Center
Toivakka, M. (PI), Rosenholm, J. (PI), Anttu, N. (PI), Bobacka, J. (PI), Huynh, T. P. (PI), Peltonen, J. (PI), Wang, X. (PI), Wilen, C.-E. (PI), Xu, C. (PI), Zhang, H. (PI) & Österbacka, R. (PI)
Faculty of Science and Engineering
Facility/equipment: Facility

1 Finished
1 Active

FCFH: Finland-China Network in Food and Health Sciences
Rosenholm, J. (Principal Investigator), Xu, C. (Principal Investigator) & Zhang, H. (Principal Investigator)
Ministry of Education and Culture
01/01/21 → 31/12/24
Project: Ministry / Government Agency
Targeted delivery of CRISPR/Cas9 for advanced liver cancer therapy through c-Myc knockout
Zhang, H. (Principal Investigator)
01/09/19 → 31/08/24
Project: Research Council of Finland/Other Research Councils

Cite this

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title = "Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy",

abstract = "Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.",

author = "Jiaqi Yan and Haixia Zou and Wenhui Zhou and Xiaowan Yuan and Zhijun Li and Xiaodong Ma and Chang Liu and Yonghui Wang and Rosenholm, {Jessica M.} and Wenguo Cui and Xiangmeng Qu and Hongbo Zhang",

year = "2022",

month = jun,

day = "20",

doi = "10.1039/D2BM00640E",

language = "English",

volume = "10",

pages = "4119--4125",

journal = "Biomaterials Science",

issn = "2047-4849",

publisher = "Royal Society of Chemistry",

number = "15",

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TY - JOUR

T1 - Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy

AU - Yan, Jiaqi

AU - Zou, Haixia

AU - Zhou, Wenhui

AU - Yuan, Xiaowan

AU - Li, Zhijun

AU - Ma, Xiaodong

AU - Liu, Chang

AU - Wang, Yonghui

AU - Rosenholm, Jessica M.

AU - Cui, Wenguo

AU - Qu, Xiangmeng

AU - Zhang, Hongbo

PY - 2022/6/20

Y1 - 2022/6/20

N2 - Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.

AB - Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.

U2 - 10.1039/D2BM00640E

DO - 10.1039/D2BM00640E

M3 - Article

SN - 2047-4849

VL - 10

SP - 4119

EP - 4125

JO - Biomaterials Science

JF - Biomaterials Science

IS - 15

ER -

Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy

Abstract

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Equipment

Åbo Akademi Functional Printing Center

Projects

FCFH: Finland-China Network in Food and Health Sciences

Targeted delivery of CRISPR/Cas9 for advanced liver cancer therapy through c-Myc knockout

Cite this