Projects per year
Abstract
Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.
Original language | English |
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Pages (from-to) | 4119-4125 |
Number of pages | 7 |
Journal | Biomaterials Science |
Volume | 10 |
Issue number | 15 |
DOIs | |
Publication status | Published - 20 Jun 2022 |
MoE publication type | A1 Journal article-refereed |
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Åbo Akademi Functional Printing Center
Martti Toivakka (PI), Jessica Rosenholm (PI), Nicklas Anttu (PI), Johan Bobacka (PI), Tan Phat Huynh (PI), Jouko Peltonen (PI), Xiaoju Wang (PI), Carl-Eric Wilen (PI), Chunlin Xu (PI), Hongbo Zhang (PI) & Ronald Österbacka (PI)
Faculty of Science and EngineeringFacility/equipment: Facility
Projects
- 2 Active
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FCFH: Finland-China Network in Food and Health Sciences
Rosenholm, J., Xu, C. & Zhang, H.
Ministry of Education and Culture
01/01/21 → 31/12/24
Project: Ministry / Government Agency
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Targeted delivery of CRISPR/Cas9 for advanced liver cancer therapy through c-Myc knockout
01/09/19 → 31/08/24
Project: Academy of Finland/Other Research Councils