Roles of vimentin in health and disease

Karen M Ridge, John E Eriksson, Milos Pekny, Robert D Goldman

Research output: Contribution to journalReview Article or Literature Reviewpeer-review

81 Citations (Scopus)
61 Downloads (Pure)

Abstract

More than 27 yr ago, the vimentin knockout (Vim-/- ) mouse was reported to develop and reproduce without an obvious phenotype, implying that this major cytoskeletal protein was nonessential. Subsequently, comprehensive and careful analyses have revealed numerous phenotypes in Vim-/- mice and their organs, tissues, and cells, frequently reflecting altered responses in the recovery of tissues following various insults or injuries. These findings have been supported by cell-based experiments demonstrating that vimentin intermediate filaments (IFs) play a critical role in regulating cell mechanics and are required to coordinate mechanosensing, transduction, signaling pathways, motility, and inflammatory responses. This review highlights the essential functions of vimentin IFs revealed from studies of Vim-/- mice and cells derived from them.

Original languageEnglish
Pages (from-to)391-407
Number of pages17
JournalGenes and Development
Volume36
Issue number7-8
DOIs
Publication statusPublished - 1 Apr 2022
MoE publication typeA2 Review article in a scientific journal

Keywords

  • Animals
  • Cell Physiological Phenomena
  • Intermediate Filaments/genetics
  • Mice
  • Vimentin/genetics

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