Robust strategies in nuclear-targeted cancer therapy based on functional nanomaterials

Xiaofei Qin, Hanyi Zhang, Xin Xing, Peng Wang, Jiaqi Yan, Daishun Liu, Qiuyu Gong, Renshuai Zhang, Hongbo Zhang*

*Corresponding author for this work

Research output: Contribution to journalReview Article or Literature Reviewpeer-review

12 Citations (Scopus)
51 Downloads (Pure)


Nucleus, as the machinery for genome transcription, play prominent roles to support the fundamental cellular functions, the destruction of any of these specific parts would significantly modulate the cell function. Therefore, troumendous drug delivery systems with enhanced nucleus targeting ability have been studied for nucleus-related disease regulation. The purpose of this review is to sort out the fundamental nuclear targeting strategy, especially the active mechanism of various nuclear targeting ligands and their extensive applications based on cancer targeting therapy. Various nuclear targeting ligands are first introduced to understand their nuclear entry mechanism. Next, to overcome biological barriers and avoid the serum protein absorption, diverse robust delivery strategies based on different nuclear targeting ligands are discussed. Moreover, other sophisticated carrier systems with enhanced nuclear entry, while without nuclear targeting ligands are also assembled. At the end the challenges and future opportunities in the field of nuclear targeting nanotherapeutics are tentatively proposed, to speed up their clinical translation.

Original languageEnglish
Article number110999
Number of pages18
JournalMaterials and Design
Publication statusPublished - Sept 2022
MoE publication typeA2 Review article in a scientific journal


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