Rhamnosylation of lignans by a Streptomyces strain

Patrik Christoffer Eklund; Toni Holmström; Lamis Al-Ubaydy; Rainer Sjöholm; Juha Hakala

doi:10.1016/j.tetlet.2005.12.107

Rhamnosylation of lignans by a Streptomyces strain

Patrik Christoffer Eklund, Toni Holmström, Lamis Al-Ubaydy, Rainer Sjöholm, Juha Hakala

Research output: Contribution to journal › Article › Scientific › peer-review

6 Citations (Scopus)

Abstract

Screening of 400 Streptomyces strains for biotransformation of the natural lignan matairesinol led to the identification of Streptomyces sp. LS136, capable of producing a single metabolite in moderate yields. Isolation and purification by preparative HPLC, followed by structural analyses by LC-MS and NMR, established the structure as matairesinol-4-O-rhamnoside. This bacterial strain was also used for rhamnosylation of the abundant natural lignans, hydroxymatairesinol and secoisolariciresinol. (c) 2006 Elsevier Ltd. All rights reserved.

Original language	Undefined/Unknown
Pages (from-to)	1645–1648
Number of pages	4
Journal	Tetrahedron Letters
Volume	47
Issue number	10
DOIs	https://doi.org/10.1016/j.tetlet.2005.12.107
Publication status	Published - 2006
MoE publication type	A1 Journal article-refereed

Access to Document

10.1016/j.tetlet.2005.12.107

Cite this

@article{08a048b046a247fd8997e8f8e38d4874,

title = "Rhamnosylation of lignans by a Streptomyces strain",

abstract = "Screening of 400 Streptomyces strains for biotransformation of the natural lignan matairesinol led to the identification of Streptomyces sp. LS136, capable of producing a single metabolite in moderate yields. Isolation and purification by preparative HPLC, followed by structural analyses by LC-MS and NMR, established the structure as matairesinol-4-O-rhamnoside. This bacterial strain was also used for rhamnosylation of the abundant natural lignans, hydroxymatairesinol and secoisolariciresinol. (c) 2006 Elsevier Ltd. All rights reserved.",

author = "Eklund, {Patrik Christoffer} and Toni Holmstr{\"o}m and Lamis Al-Ubaydy and Rainer Sj{\"o}holm and Juha Hakala",

year = "2006",

doi = "10.1016/j.tetlet.2005.12.107",

language = "Odefinierat/ok{\"a}nt",

volume = "47",

pages = "1645–1648",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier",

number = "10",

}

TY - JOUR

T1 - Rhamnosylation of lignans by a Streptomyces strain

AU - Eklund, Patrik Christoffer

AU - Holmström, Toni

AU - Al-Ubaydy, Lamis

AU - Sjöholm, Rainer

AU - Hakala, Juha

PY - 2006

Y1 - 2006

N2 - Screening of 400 Streptomyces strains for biotransformation of the natural lignan matairesinol led to the identification of Streptomyces sp. LS136, capable of producing a single metabolite in moderate yields. Isolation and purification by preparative HPLC, followed by structural analyses by LC-MS and NMR, established the structure as matairesinol-4-O-rhamnoside. This bacterial strain was also used for rhamnosylation of the abundant natural lignans, hydroxymatairesinol and secoisolariciresinol. (c) 2006 Elsevier Ltd. All rights reserved.

AB - Screening of 400 Streptomyces strains for biotransformation of the natural lignan matairesinol led to the identification of Streptomyces sp. LS136, capable of producing a single metabolite in moderate yields. Isolation and purification by preparative HPLC, followed by structural analyses by LC-MS and NMR, established the structure as matairesinol-4-O-rhamnoside. This bacterial strain was also used for rhamnosylation of the abundant natural lignans, hydroxymatairesinol and secoisolariciresinol. (c) 2006 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.tetlet.2005.12.107

DO - 10.1016/j.tetlet.2005.12.107

M3 - Artikel

SN - 0040-4039

VL - 47

SP - 1645

EP - 1648

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 10

ER -