Rhamnosylation of lignans by a Streptomyces strain

Patrik Christoffer Eklund, Toni Holmström, Lamis Al-Ubaydy, Rainer Sjöholm, Juha Hakala

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    Screening of 400 Streptomyces strains for biotransformation of the natural lignan matairesinol led to the identification of Streptomyces sp. LS136, capable of producing a single metabolite in moderate yields. Isolation and purification by preparative HPLC, followed by structural analyses by LC-MS and NMR, established the structure as matairesinol-4-O-rhamnoside. This bacterial strain was also used for rhamnosylation of the abundant natural lignans, hydroxymatairesinol and secoisolariciresinol. (c) 2006 Elsevier Ltd. All rights reserved.
    Original languageUndefined/Unknown
    Pages (from-to)1645–1648
    Number of pages4
    JournalTetrahedron Letters
    Issue number10
    Publication statusPublished - 2006
    MoE publication typeA1 Journal article-refereed

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