Regulation of the members of the mammalian heat shock factor family

Johanna K Björk, Lea Sistonen

Research output: Contribution to journalReview Article or Literature Reviewpeer-review


Regulation of gene expression is fundamental in all living organisms and is facilitated by transcription factors, the single largest group of proteins in humans. For cell- and stimulus-specific gene regulation, strict control of the transcription factors themselves is crucial. Heat shock factors are a family of transcription factors best known as master regulators of induced gene expression during the heat shock response. This evolutionary conserved cellular stress response is characterized by massive production of heat shock proteins, which function as cytoprotective molecular chaperones against various proteotoxic stresses. In addition to promoting cell survival under stressful conditions, heat shock factors are involved in the regulation of life span and progression of cancer and they are also important for developmental processes such as gametogenesis, neurogenesis and maintenance of sensory organs. Here, we review the regulatory mechanisms steering the activities of the mammalian heat shock factors 1–4.

Original languageEnglish
Pages (from-to)4126-39
Number of pages14
JournalFEBS Journal
Issue number20
Publication statusPublished - Oct 2010
MoE publication typeA2 Review article in a scientific journal


  • Animals
  • Gene Expression Regulation/physiology
  • Heat-Shock Proteins/genetics
  • Heat-Shock Response/physiology
  • Humans
  • Mammals


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