TY - JOUR
T1 - Recombination Monophosphoryl Lipid A-Derived Vacosome for the Development of Preventive Cancer Vaccines
AU - Cheng, Ruoyu
AU - Fontana, Flavia
AU - Xiao, Junyuan
AU - Liu, Zehua
AU - Figueiredo, Patricia
AU - Shahbazi, Mohammad-Ali
AU - Wang, Shiqi
AU - Jin, Jing
AU - Torrieri, Giulia
AU - Hirvonen, Jouni Tapio
AU - Zhang, Hongbo
AU - Chen, Tongtong Chen
AU - Cui, Wenguo
AU - Lu, Yong
AU - Santos, Hélder A.
PY - 2020/10/7
Y1 - 2020/10/7
N2 - Recently, there has been an increasing interest for utilizing the host immune system to fight against cancer. Moreover, cancer vaccines, which can stimulate the host immune system to respond to cancer in the long term, are being investigated as a promising approach to induce tumor-specific immunity. In this work, we prepared an effective cancer vaccine (denoted as "vacosome") by reconstructing the cancer cell membrane, monophosphoryl lipid A as a toll-like receptor 4 agonist, and egg phosphatidylcholine. The vacosome triggered and enhanced bone marrow dendritic cell maturation as well as stimulated the antitumor response against breast cancer 4T1 cells in vitro. Furthermore, an immune memory was established in BALB/c mice after three-time preimmunization with the vacosome. After that, the immunized mice showed inhibited tumor growth and prolonged survival period (longer than 50 days). Overall, our results demonstrate that the vacosome can be a potential candidate for clinical translation as a cancer vaccine.
AB - Recently, there has been an increasing interest for utilizing the host immune system to fight against cancer. Moreover, cancer vaccines, which can stimulate the host immune system to respond to cancer in the long term, are being investigated as a promising approach to induce tumor-specific immunity. In this work, we prepared an effective cancer vaccine (denoted as "vacosome") by reconstructing the cancer cell membrane, monophosphoryl lipid A as a toll-like receptor 4 agonist, and egg phosphatidylcholine. The vacosome triggered and enhanced bone marrow dendritic cell maturation as well as stimulated the antitumor response against breast cancer 4T1 cells in vitro. Furthermore, an immune memory was established in BALB/c mice after three-time preimmunization with the vacosome. After that, the immunized mice showed inhibited tumor growth and prolonged survival period (longer than 50 days). Overall, our results demonstrate that the vacosome can be a potential candidate for clinical translation as a cancer vaccine.
UR - http://dx.doi.org/10.1021/acsami.0c15057
U2 - 10.1021/acsami.0c15057
DO - 10.1021/acsami.0c15057
M3 - Article
VL - 12
SP - 44554
EP - 44562
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
SN - 1944-8244
IS - 40
ER -