Recombination Monophosphoryl Lipid A-Derived Vacosome for the Development of Preventive Cancer Vaccines

Ruoyu Cheng, Flavia Fontana, Junyuan Xiao, Zehua Liu, Patricia Figueiredo, Mohammad-Ali Shahbazi, Shiqi Wang, Jing Jin, Giulia Torrieri, Jouni Tapio Hirvonen, Hongbo Zhang, Tongtong Chen Chen, Wenguo Cui, Yong Lu, Hélder A. Santos

Research output: Contribution to journalArticleScientificpeer-review

2 Citations (Scopus)
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Abstract

Recently, there has been an increasing interest for utilizing the host immune system to fight against cancer. Moreover, cancer vaccines, which can stimulate the host immune system to respond to cancer in the long term, are being investigated as a promising approach to induce tumor-specific immunity. In this work, we prepared an effective cancer vaccine (denoted as "vacosome") by reconstructing the cancer cell membrane, monophosphoryl lipid A as a toll-like receptor 4 agonist, and egg phosphatidylcholine. The vacosome triggered and enhanced bone marrow dendritic cell maturation as well as stimulated the antitumor response against breast cancer 4T1 cells in vitro. Furthermore, an immune memory was established in BALB/c mice after three-time preimmunization with the vacosome. After that, the immunized mice showed inhibited tumor growth and prolonged survival period (longer than 50 days). Overall, our results demonstrate that the vacosome can be a potential candidate for clinical translation as a cancer vaccine.

Original languageEnglish
Pages (from-to)44554-44562
Number of pages9
JournalACS Applied Materials and Interfaces
Volume12
Issue number40
DOIs
Publication statusPublished - 7 Oct 2020
MoE publication typeA1 Journal article-refereed

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