Abstract
The objective of this review is to provide a comprehensive summary of the latest methodological advancements and emerging patterns in utilizing lipidomics in clinical research.In this review, we assess the recent advancements in lipidomics methodologies that exhibit high levels of selectivity and sensitivity, capable of generating numerous molecular lipid species from limited quantities of biological matrices. The reviewed studies demonstrate that molecular lipid signatures offer new opportunities for precision medicine by providing sensitive diagnostic tools for disease prediction and monitoring. Moreover, the latest innovations in microsampling techniques have the potential to make a substantial contribution to clinical lipidomics. The review also shows that more work is needed to harmonize results across diverse lipidomics platforms and avoid significant errors in analysis and reporting. The increased implementation of internal standards and standard reference materials in analytical workflows will aid in this direction.
| Original language | English |
|---|---|
| Article number | 102370 |
| Number of pages | 9 |
| Journal | Current Opinion in Chemical Biology |
| Volume | 76 |
| DOIs | |
| Publication status | Published - Oct 2023 |
| MoE publication type | A2 Review article in a scientific journal |
Funding
This review preparation was supported by “Inflammation in human early life: targeting impacts on life-course health” (INITIALISE) consortium funded by the Horizon Europe Program of the European Union under Grant Agreement 101094099 (to M.O. and T.H.) and Academy of Finland (grant no. 333981 to M.O.).
Keywords
- Biomarkers
- Human health
- Lipidomics
- Mass spectrometry
- Microsampling