Providing cellular signposts--post-translational modifications of intermediate filaments

Claire Hyder, Pallari, Vitaly Kochin, John Eriksson

    Research output: Contribution to journalReview Article or Literature ReviewScientificpeer-review

    61 Citations (Scopus)

    Abstract

    Intermediate filaments are dynamically regulated by their post-translational modifications. Initially these modifications were found to regulate filament dynamics and organization. In the last few years, their roles have extended significantly to facilitating, for example, the recruitment and sequestration of signaling molecules that regulate a wide range of cellular functions. While phosphorylation has been established as the principal post-translational modification regulating intermediate filament function, other modifications with co-operative roles are emerging, adding a further dimensions to intermediate filament-mediated signaling.
    Original languageUndefined/Unknown
    Pages (from-to)2140–2148
    JournalFEBS Letters
    Volume582
    Issue number14
    DOIs
    Publication statusPublished - 2008
    MoE publication typeA2 Review article in a scientific journal

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