Precipitation of Inorganic Salts in Mitochondrial Matrix

Jerzy J. Jasielec, Robert Filipek, Krzysztof Dołowy, Andrzej Lewenstam

    Research output: Contribution to journalArticleScientificpeer-review

    2 Citations (Scopus)

    Abstract

    In the mitochondrial matrix, there are insoluble, osmotically inactive complexes that maintain a constant pH and calcium concentration. In the present paper, we examine the properties of insoluble calcium and magnesium salts, such as phosphates, carbonates and polyphosphates, which might play this role. We find that non-stoichiometric, magnesium-rich carbonated apatite, with very low crystallinity, precipitates in the matrix under physiological conditions. Precipitated salt acts as pH buffer, and, hence, can contribute in maintaining ATP production in ischemic conditions, which delays irreversible damage to heart and brain cells after stroke.
    Original languageEnglish
    JournalMembranes
    Volume10
    Issue number5
    DOIs
    Publication statusPublished - 2020
    MoE publication typeA1 Journal article-refereed

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