Abstract
Protein phosphatase 2A (PP2A) is a highly complex heterotrimeric Ser/Thr phosphatase that regulates many cellular processes. The role of PP2A as a tumor suppressor has been extensively studied and reviewed. However, emerging evidence suggests PP2A constrains inflammatory responses and is important in autoimmune and neuroinflammatory diseases. Here, we reviewed the existing literature on the role of PP2A in T-cell differentiation and autoimmunity. We have also discussed the modulation of PP2A activity by endogenous inhibitors and its small-molecule activators as potential therapeutic approaches against autoimmunity.
| Original language | English |
|---|---|
| Article number | 786857 |
| Journal | Frontiers in Immunology |
| Volume | 12 |
| DOIs | |
| Publication status | Published - 5 Jan 2022 |
| MoE publication type | A2 Review article in a scientific journal |
Funding
MMK was supported by the University of Turku graduate school on Turku Doctoral Programme of Molecular Medicine (TuDMM) and a central grant from the Finnish Cultural Foundation. UK was supported by Varsinais-Suomi regional Fund from Finnish Cultural Foundation. RL was supported by the Academy of Finland, AoF, Centre of Excellence in Molecular Systems Immunology and Physiology Research (2012-2017) grant 250114; by the AoF grants 292335, 294337, 292482, 31444, 335435, 331793, 329277, and by grants from the JDRF, the Sigrid Jusélius Foundation, the Jane and Aatos Erkko Foundation and the Finnish Cancer Foundation.
Keywords
- autoimmune disease
- inflammatory
- PP2A
- PP2A activating drugs
- T cell differentiation