PP2A and Its Inhibitors in Helper T-Cell Differentiation and Autoimmunity

Mohd Moin Khan, Ubaid Ullah Kalim, Meraj H. Khan, Riitta Lahesmaa*

*Corresponding author for this work

Research output: Contribution to journalReview Article or Literature Reviewpeer-review

5 Citations (Scopus)
2 Downloads (Pure)


Protein phosphatase 2A (PP2A) is a highly complex heterotrimeric Ser/Thr phosphatase that regulates many cellular processes. The role of PP2A as a tumor suppressor has been extensively studied and reviewed. However, emerging evidence suggests PP2A constrains inflammatory responses and is important in autoimmune and neuroinflammatory diseases. Here, we reviewed the existing literature on the role of PP2A in T-cell differentiation and autoimmunity. We have also discussed the modulation of PP2A activity by endogenous inhibitors and its small-molecule activators as potential therapeutic approaches against autoimmunity.

Original languageEnglish
Article number786857
JournalFrontiers in Immunology
Publication statusPublished - 5 Jan 2022
MoE publication typeA2 Review article in a scientific journal


  • autoimmune disease
  • inflammatory
  • PP2A
  • PP2A activating drugs
  • T cell differentiation


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