Postprandial Oxidative Metabolism of Human Brown Fat Indicates Thermogenesis

MU Din, T Saari, J Raiko, N Kudomi, SF Maurer, M Lahesmaa, T Fromme, EZ Amri, M Klingenspor, Olof Solin, P Nuutila, KA Virtanen

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    78 Citations (Scopus)

    Abstract

    Human studies suggest that a meal elevates glucose uptake in brown adipose tissue (BAT). However, in postprandial state the thermogenic activity and the metabolism of non-esterified fatty acids (NEFAs) in BAT remain unclear. Using indirect calorimetry combined with positron emission tomography and computed tomography (PET/CT), we showed that whole-body and BAT thermogenesis (oxygen consumption) increases after the ingestion of a mixed carbohydrate-rich meal, to the same extent as in cold stress. Postprandial NEFA uptake into BAT is minimal, possibly due to elevated plasma insulin inhibiting lipolysis. However, the variation in postprandial NEFA uptake is linked to BAT thermogenesis. We identified several genes participating in lipid metabolism to be expressed at higher levels in BAT compared with white fat in postprandial state, and to be positively correlated with BAT UCP1 expression. These findings suggest that substrates preferred by BAT in postprandial state are glucose or LPL-released NEFAs due to insulin stimulation.
    Original languageUndefined/Unknown
    Pages (from-to)207–216
    Number of pages13
    JournalCell Metabolism
    Volume28
    Issue number2
    DOIs
    Publication statusPublished - 2018
    MoE publication typeA1 Journal article-refereed

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