Polysaccharide-and β-cyclodextrin-based chiral selectors for enantiomer resolution: Recent developments and applications

Cuong Viet Bui, Thomas Rosenau, Hubert Hettegger*

*Corresponding author for this work

Research output: Contribution to journalReview Article or Literature Reviewpeer-review

9 Citations (Scopus)
57 Downloads (Pure)


Polysaccharides, oligosaccharides, and their derivatives, particularly of amylose, cellu-lose, chitosan, and β-cyclodextrin, are well-known chiral selectors (CSs) of chiral stationary phases (CSPs) in chromatography, because they can separate a wide range of enantiomers. Typically, such CSPs are prepared by physically coating, or chemically immobilizing the polysaccharide and β-cy-clodextrin derivatives onto inert silica gel carriers as chromatographic support. Over the past few years, new chiral selectors have been introduced, and progressive methods to prepare CSPs have been exploited. Also, chiral recognition mechanisms, which play a crucial role in the investigation of chiral separations, have been better elucidated. Further insights into the broad functional performance of commercially available chiral column materials and/or the respective newly developed chiral phase materials on enantiomeric separation (ES) have been gained. This review summarizes the recent developments in CSs, CSP preparation, chiral recognition mechanisms, and enantiomeric separation methods, based on polysaccharides and β-cyclodextrins as CSs, with a focus on the years 2019–2020 of this rapidly developing field.

Original languageEnglish
Article number4322
Issue number14
Publication statusPublished - 2 Jul 2021
MoE publication typeA2 Review article in a scientific journal


  • Amylose
  • Cellulose
  • Chiral selector
  • Chiral stationary phase
  • Chromatography
  • Cyclodex-trin
  • Enantiomer separation
  • Polysaccharide


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